3,7-Dibenzyl-3,7-diazabicyclo[3.3.1]nonane → 3-Benzyl-3,7-diazabicyclo[3.3.1]nonane

HRID 991486

反応式

HRID 991486 の反応式
[CH2:1]([N:8]1[CH2:15][CH:14]2[CH2:16][CH:10]([CH2:11][N:12](CC3C=CC=CC=3)[CH2:13]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([N:8]1[CH2:9][CH:10]2[CH2:16][CH:14]([CH2:13][NH:12][CH2:11]2)[CH2:15]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 473413,7-Dibenzyl-3,7-diazabicyclo[3.3.1]nonane

生成物 1

HCID 130594823-Benzyl-3,7-diazabicyclo[3.3.1]nonane

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 3,7-dibenzyl-3,7-diazabicyclo[3.3.1]nonane (from step (ii) above; 97 g; 6.4 mmol) in aqueous ethanol (95%) was hydrogenated over 5% Pd/C at 1 atm. until tic indicated that the reaction was complete. The catalyst was removed by filtration through a pad of Celite®, and the filtrate concentrated under reduced pressure to give the sub-title compound in quantitative yield.

後処理

  1. customThe catalyst was removed by filtration through a pad of Celite®
  2. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a66ea2ed9f854dca8d4a11e137a41558
出典データセット
uspto-grants-2002_10
特許番号
US06465481B1

関連ノート

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