Sodium hydride → 4-{2-[(3-Chloro-2-pyrazinyl)oxy]ethoxy}-1,3-benzoxazol-2-amine

反応式

[H-].[Na+].Cl[C:4]1[C:9]([Cl:10])=[N:8][CH:7]=[CH:6][N:5]=1.[OH:11][CH2:12][CH2:13][O:14][C:15]1[C:20]2[N:21]=[C:22]([NH2:24])[O:23][C:19]=2[CH:18]=[CH:17][CH:16]=1>>[Cl:10][C:9]1[C:4]([O:11][CH2:12][CH2:13][O:14][C:15]2[C:20]3[N:21]=[C:22]([NH2:24])[O:23][C:19]=3[CH:18]=[CH:17][CH:16]=2)=[N:5][CH:6]=[CH:7][N:8]=1

参加物

反応物 3

HCID 24758Sodium hydride

HCID 785752,3-Dichloropyrazine

HCID 220364604-(2-Hydroxyethoxy)-2-amino-1,3-benzoxazol

生成物 1

HCID 539867324-{2-[(3-Chloro-2-pyrazinyl)oxy]ethoxy}-1,3-benzoxazol-2-amine

実験手順

The title compound was prepared according to the procedure of Example 4, Step 1, except that 4 equiv of both NaH and 2,3-dichloropyrazine were used, starting from the product of Step 1. The reaction temperature was 90° C. The crude product was used directly in the next step.