Acetic Acid → 3-Nitrotricyclo(3.3.1.13,7)decane-1-carboxylic acid

HRID 992156

反応式

HRID 992156 の反応式
[C:1]([C:4]12[CH2:13][CH:8]3[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]3)[CH2:5]1)[CH2:11]2)([OH:3])=[O:2].[OH:14][N:15]1C(=O)C2=CC=CC=C2C1=O.C(O)(=[O:28])C>>[C:1]([C:4]12[CH2:13][CH:8]3[CH2:7][CH:6]([CH2:12][C:10]([N+:15]([O-:14])=[O:28])([CH2:9]3)[CH2:11]1)[CH2:5]2)([OH:3])=[O:2]

参加物

4

反応物 3

HCID 176Acetic AcidHCID 10665N-HydroxyphthalimideHCID 132351-Adamantanecarboxylic acid2 回

生成物 1

HCID 392393-Nitrotricyclo(3.3.1.13,7)decane-1-carboxylic acid収率 80%

実験手順

Into a flask, 1 mmole of 1-carboxyadamantane, 0.1 mmole of N-hydroxyphthalimide and 6 ml of acetic acid were added to mix. The mixture was purged by nitrogen monoxide NO (about 1L) and oxygen O2 (about 1L), and then reacted for 20 hours at 110° C. with stirring. The reaction products were analyzed by gas chromatography, and, as a result, the conversion of 1-carboxyadamantane was 90%, and 1-carboxy-3-nitroadamantane (yield 80%) was formed.

後処理

  1. additionto mix
  2. customThe mixture was purged by nitrogen monoxide NO (about 1L) and oxygen O2 (about 1L)
  3. customreacted for 20 hours at 110° C.

出典と根拠

ORDレコード
ord-dfd3540c043044058646b3a81bad990c
出典データセット
uspto-grants-2002_10
特許番号
US06468487B1

関連ノート

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