Acetyl chloride → 1,3-Bis(acetylamino)adamantane

HRID 992161

反応式

HRID 992161 の反応式
[C:1](Cl)(=[O:3])[CH3:2].C(N(CC)CC)C.[NH2:12][C:13]12[CH2:22][CH:17]3[CH2:18][CH:19]([CH2:21][C:15]([NH2:23])([CH2:16]3)[CH2:14]1)[CH2:20]2.[O:24]1CC[CH2:26][CH2:25]1>CN(C)C=O>[C:1]([NH:12][C:13]12[CH2:22][CH:17]3[CH2:18][CH:19]([CH2:21][C:15]([NH:23][C:25](=[O:24])[CH3:26])([CH2:16]3)[CH2:14]1)[CH2:20]2)(=[O:3])[CH3:2]

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 213512Adamantane-1,3-diamine2 回

生成物 1

HCID 28177971,3-Bis(acetylamino)adamantane収率 95%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
40 °C

実験手順

In an atmosphere of nitrogen, 22 mmole of acetyl chloride and 24 mmole of triethylamine were dissolved in 2 ml of tetrahydrofurane (THF). To the resultant solution, 10 ml of solution containing 10 mmole of 1,3-diaminoadamantane obtained by the method of Example 65 in N,N-dimethylformamide (DMF) was added and then stirred for 3 hours at 40° C. As a result, the conversion of 1,3-diaminoadamantane was 99%, and 1,3-bis(acetylamino)adamantane (yield 95%) was formed.

後処理

  1. additionwas added

出典と根拠

ORDレコード
ord-dda9b35d9b2e4a14a9ebecad2e5bca03
出典データセット
uspto-grants-2002_10
特許番号
US06468487B1

関連ノート

読み込み中…