Dimethylamine → 1-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantane

HRID 992164ノート

反応式

HRID 992164 の反応式
[CH3:1][NH:2][CH3:3].[CH3:4][O:5][C:6]([C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][C:10]([C:18]([O:20]C)=O)([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:7]>C1COCC1>[CH3:4][O:5][C:6]([C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][C:10]([C:18](=[O:20])[N:2]([CH3:3])[CH3:1])([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:7]

参加物

4

反応物 2

HCID 674DimethylamineHCID 365223Dimethyl 1,3-adamantanedicarboxylate

生成物 1

HCID 184104771-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantane収率 80%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1 mmole of 1,3-bis(methozxycarbonyl)adamantane obtained by the method of Example 84 was dissolved in 30 ml of THF. To the mixture, 0.5 mmole of dimethylamine and 0.1 mmole of aluminum chloride anhydride AlCl3 was added and reacted for 6 hours at 80° C. As a result, The conversion of 1,3-bis(methoxycarbonyl)adamantane was 90%, and 1-methoxycarbonyl-3-(N,N-dimethylcarbamoyl)adamantane (yield 80%) was formed.

後処理

  1. customreacted for 6 hours at 80° C

出典と根拠

ORDレコード
ord-412942a19b374c38be373ab763298900
出典データセット
uspto-grants-2002_10
特許番号
US06468487B1

反応ノート

読み込み中…