Ozone → HCID 85753990、化合物

HRID 992838ノート

反応式

HRID 992838 の反応式
[CH3:1][CH2:2][CH2:3][CH:4]([C:6]1([CH2:15][CH:16]=C)[C:13](=[O:14])[N-:12][C:10](=[O:11])[NH:9][C:7]1=[O:8])[CH3:5].[Na+].[O:19]=[O+][O-]>CO>[CH3:5][CH:4]([C:6]1([CH2:15][CH:16]=[O:19])[C:7](=[O:8])[NH:9][C:10](=[O:11])[NH:12][C:13]1=[O:14])[CH2:3][CH2:2][CH3:1]

参加物

4

反応物 2

HCID 24823OzoneHCID 14148199309-43-3

生成物 1

HCID 85753990HCID 85753990、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of sodium secobarbital (5.30 g, 22.2 mmol) in methanol was passed a stream of ozone until the solution turned a blue color. After excess ozone was removed by passing nitrogen through the reaction dimethyl sulfide (14 mL) was added. The reaction was stirred at room temperature overnight before solvents were removed on a rotovap. The aldehyde was then purified on silica prep plates using ethyl acetate:hexanes (1:1).

後処理

  1. customAfter excess ozone was removed
  2. customthrough the reaction dimethyl sulfide (14 mL)
  3. additionwas added
  4. customwere removed on a rotovap
  5. customThe aldehyde was then purified on silica prep plates

出典と根拠

ORDレコード
ord-297627d4a007406daa837cbd3758e511
出典データセット
uspto-grants-2002_10
特許番号
US06472227B1

反応ノート

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