Urea → 5-(Butan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
反応式
[Na].[CH:2]([CH:6]([C:11]([O:13]C)=O)[C:7]([O:9]C)=O)([CH2:4][CH3:5])[CH3:3].[NH2:15][C:16]([NH2:18])=[O:17]>C(O)C>[CH:2]([CH:6]1[C:7](=[O:9])[NH:18][C:16](=[O:17])[NH:15][C:11]1=[O:13])([CH2:4][CH3:5])[CH3:3]参加物
5
実験手順
110 mL of anhydrous ethanol was reacted with 7.72 g of sodium metal. Subsequently 17.6 g (0.1 mol) of dimethyl secbutylmalonate was added, followed (after about 5 minutes) by urea (6.72 g). The reaction mixture was refluxed for 15 hours and 60 mL of ethanol was distilled off. 200 mL of water was added to the residue followed by 20 mL of concentrated sulfuric acid. Precipitated crystals were filtered off. The product was then recrystallized from water to yield 8 g of colorless crystals.
後処理
- custom(after about 5 minutes)
- temperatureThe reaction mixture was refluxed for 15 hours
- distillation60 mL of ethanol was distilled off
- addition200 mL of water was added to the residue
- customPrecipitated crystals
- filtrationwere filtered off
- customThe product was then recrystallized from water
出典と根拠
- ORDレコード
- ord-7c3b6fcc29804eaba482e4b443da105d
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06472227B1
反応ノート
読み込み中…