Urea → 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(3-methyl-2-butenyl)-
反応式
[Na].[NH2:2][C:3]([NH2:5])=[O:4].[CH2:6]([CH:11]([C:17](OCC)=[O:18])[C:12](OCC)=[O:13])[CH:7]=[C:8]([CH3:10])[CH3:9]>C(O)C>[CH3:9][C:8]([CH3:10])=[CH:7][CH2:6][CH:11]1[C:12](=[O:13])[NH:5][C:3](=[O:4])[NH:2][C:17]1=[O:18]参加物
5
実験手順
To a solution of 70 mg sodium (3.03 mmol) in 1.0 mL absolute ethanol was added 61 mg urea (1.01 mmol), followed by 200 mg of the diethyl prenylmalonate (0.88 mmol) prepared in the previous experiment. The solution was refluxed gently for 12 hours. Most of the ethanol was removed by rotary evaporation, and the residue was diluted in water. The solution was acidified to pH 3 and extracted 2×10 mL with ethyl acetate. The combined organic phases were dried over anhydrous magnesium sulfate and concentrated to 214 mg of an off-white solid.
後処理
- customprepared in the previous experiment
- temperatureThe solution was refluxed gently for 12 hours
- customMost of the ethanol was removed by rotary evaporation
- additionthe residue was diluted in water
- extractionextracted 2×10 mL with ethyl acetate
- dry with materialThe combined organic phases were dried over anhydrous magnesium sulfate
- concentrationconcentrated to 214 mg of an off-white solid
出典と根拠
- ORDレコード
- ord-aa3e50c6ae8d4c82bcfc4144ca17bec9
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06472227B1
反応ノート
読み込み中…