Thionyl Chloride → HCID 12010380、化合物

HRID 992986ノート

反応式

HRID 992986 の反応式
O[CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[S:6][CH:7]=1.S(Cl)([Cl:22])=O>ClCCl>[Cl:22][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[S:6][CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 18408501HCID 18408501、化合物

生成物 1

HCID 12010380HCID 12010380、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-Hydroxymethyl-2-(3,4,5-trimethoxyphenyl)thiazole (2.0 g) was dissolved in dichloromethane (60 mL), and to the solution thionyl chloride (1.1 g) was added at 0° C. After 30 minutes, the mixture was warmed to room temperature and stirred for 4 hours. The reaction mixture was washed with water and saturated brine and dried over anhydrous sodium sulfate. After concentrating the reaction mixture under reduced pressure, the resultant crude crystals were recrystallized from chloroform-hexane to obtain the title compound.

後処理

  1. washThe reaction mixture was washed with water and saturated brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationAfter concentrating the reaction mixture under reduced pressure
  4. customthe resultant crude crystals were recrystallized from chloroform-hexane

出典と根拠

ORDレコード
ord-8adfac5c3aec49198ad8a4b90cf5a1db
出典データセット
uspto-grants-2002_10
特許番号
US06472386B1

反応ノート

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