Sodium cyanoborohydride → 5-[3-(4-Methoxyphenyl)propyl]barbituric acid

HRID 993052ノート

反応式

HRID 993052 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([CH:13]2[C:18](=[O:19])[NH:17][C:16](=[O:20])[NH:15][C:14]2=[O:21])=O)=[CH:5][CH:4]=1.C([BH3-])#N.[Na+]>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][CH2:11][CH:13]2[C:14](=[O:21])[NH:15][C:16](=[O:20])[NH:17][C:18]2=[O:19])=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 5003444Sodium cyanoborohydrideHCID 140406695-[3-(4-Methoxyphenyl)propionyl]barbituric acid

生成物 1

HCID 140406705-[3-(4-Methoxyphenyl)propyl]barbituric acid収率 91.8%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
60 °C

実験手順

To a suspension of 10 g of 5-[3-(4-Methoxyphenyl)propionyl]barbituric Acid in 100 ml of acetic acid are added portionwise 4.5 g of sodium cyanoborohydride, then the mixture is heated to 60° C. After 1 hour the reaction mixture is cooled to room temperature and poured into ice. After 30 minutes a solid is recovered by filtration, which is dried under vacuum at 50° C. to give 8.74 g of the product, m.p. 195-197° C.

後処理

  1. temperatureAfter 1 hour the reaction mixture is cooled to room temperature
  2. additionpoured into ice
  3. filtrationAfter 30 minutes a solid is recovered by filtration, which
  4. customis dried under vacuum at 50° C.

出典と根拠

ORDレコード
ord-2587492816d34123b56532bc57ad0fc3
出典データセット
uspto-grants-2002_10
特許番号
US06472396B1

反応ノート

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