4-(4-Dimethylaminosulfonylbenzyl)-nitrobenzene → 4-(4-Dimethylaminosulfonylbenzyl)-phenylamine

HRID 993388ノート

反応式

HRID 993388 の反応式
[CH3:1][N:2]([CH3:22])[S:3]([C:6]1[CH:21]=[CH:20][C:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)=[CH:8][CH:7]=1)(=[O:5])=[O:4]>C(OCC)(=O)C.[Pd]>[CH3:22][N:2]([CH3:1])[S:3]([C:6]1[CH:21]=[CH:20][C:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)=[CH:8][CH:7]=1)(=[O:4])=[O:5]

参加物

4

反応物 1

HCID 218769584-(4-Dimethylaminosulfonylbenzyl)-nitrobenzene

生成物 1

HCID 218770384-(4-Dimethylaminosulfonylbenzyl)-phenylamine収率 102.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

4-(4-Dimethylaminosulfonylbenzyl)-nitrobenzene (311 mg) was dissolved in ethyl acetate and hydrogenated at 40 psi using a 10% palladium on carbon catalyst for 2 hours. The mixture was filtered, and solvents evaporated to give 4-(4-dimethylaminosulfonylbenzyl)-phenylamine as a white solid (288 mg, 99%).

後処理

  1. customfor 2 hours
  2. filtrationThe mixture was filtered
  3. customsolvents evaporated

出典と根拠

ORDレコード
ord-806768d56c3e4ade8199e61b943a9879
出典データセット
uspto-grants-2002_10
特許番号
US06472536B1

反応ノート

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