Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Epoxy-3-fluoropropane
Oxirane, (fluoromethyl)- · WLN: T3OTJ B1F · Epifluorhydrine · EPIFLUOROHYDRIN · epifluorohydrine · cycloxyfluoropane · FLUOROMETHYLOXIRAN · Epifluorohydrin98%
식별자 및 물리적 특성
| CAS No. | 503-09-3 |
|---|---|
| 분자식 | C3H5FO |
| 평균 분자량 | 76.07 g/mol |
| 단동위원소 질량 | 76.032443 g/mol |
| SMILES | FCC1CO1 |
| InChIKey | OIFAHDAXIUURLN-UHFFFAOYSA-N |
| PubChem CID | 10418 |
| EC No. | 207-960-1 |
| DTXSID | DTXSID4025244 |
화학 및 물리적 성질
| XLogP | -0.2 |
|---|---|
| 극성 표면적 | 12.5 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 5 |
| 형식 전하 | 0 |
| 복잡도 | 37.9 |
| SpringerMaterials Properties | Boiling point |
| LogP(분배 계수) | -0.16 |
| 밀도 | 1.09 at 68 °F (NTP, 1992) - Denser than waterwill sink1.067 g/mL at 25 °C (lit.) |
| 용해도 | greater than or equal to 100 mg/mL at 61 °F (NTP, 1992) |
| 인화점 | 40 °F (NTP, 1992) |
| 끓는 점 | 185 to 187 °F at 760 mmHg (NTP, 1992)85-86 °C (lit.) |
| Physical Description | Epifluorohydrin is a clear colorless liquid. (NTP, 1992) |
| 굴절률 | n20/D 1.368(lit.) |
| 저장 조건 | 0-6°C |
| 물리적 상태 | 액체 |
| 색상 | 투명한 |
| InChI | InChI=1S/C3H5FO/c4-1-3-2-5-3/h3H,1-2H2 |
| InChIKey | OIFAHDAXIUURLN-UHFFFAOYSA-N |
| SMILES | O1CC1CF |
| NIST | Oxirane, (fluoromethyl)-(503-09-3) |
| EPA | Epifluorohydrin (503-09-3) |
화학적 성질
clear colourless liquid
안전 및 규제
| GHS 분류 | DangerH225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 운송 라벨(DOT) | Flammable Liquid Poison |
| 화재 위험 | This chemical is flammable. (NTP, 1992) |
| 건강 유해성 | ACUTE/CHRONIC HAZARDS: This compound is a lacrimator. When heated to decomposition it emits toxic fumes. (NTP, 1992) |
| 반응성 그룹 | Halogenated Organic Compounds |
| Reactivity Alerts | Highly Flammable |
| Reactivity Profile | A halogenated epoxide. Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts. The chlorinated derivative has been shown to be incompatible with aniline, strong oxidizers, sulfuric acid, isopropylamine, zinc, aluminum, iron, etc. see epichlorohydrin. |
| Air and Water Reactions | Highly flammable. Water soluble. |
| Hazard Classes and Categories | Flam. Liq. 2 (100%) |
| 소화 | Fires involving this material can be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| 응급 처치 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
용도
용도
Epifluorohydrin is used as a reagent in the synthesis of N-arylphosphoramidates. In addition, it is used in the synthesis of orally bioavailable ALK inhibitors in the treatment of tumors.
일반 설명
Clear colorless liquid.