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트리에틸아민 하이드로클로라이드

Triethylamine hydrochloride

HCID 11130
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기본 정보이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
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기본 정보

CAS
554-68-7
표준 SMILES
CCN(CC)CC.Cl
InChIKey
ILWRPSCZWQJDMK-UHFFFAOYSA-N
분자식
C6H15N.ClH
평균 분자량
137.65 g/mol
단동위원소 질량
137.0971272

이름 및 식별자

우선 이름
Triethylamine hydrochloride
IUPAC
N,N-diethylethanamine;hydrochloride
현지명
트리에틸아민 하이드로클로라이드
영어명
Triethylamine hydrochloride
분자식
C6H16ClN
분자량
137.65

이름 및 동의어

TRIETHYLAMINE HYDROCHLORIDE554-68-7Triethylammonium chlorideTRIETHYLAMINE HClEthanamine, N,N-diethyl-, hydrochlorideTriethylamine monohydrochlorideTriethylamine, hydrochlorideAmine, triethyl, hydrochloride0NX3818GCWNSC-30600Ethanamine, N,N-diethyl-, hydrochloride (1:1)DTXSID8060292
이름 더 보기
트리에틸아민하이드로클로라이드염화트리에틸암모늄트라이에틸아민 하이드로클로라이드Et3·HCl[E3N]HClTrimethylamine HciTriethylamine hydrocTriethylammoniumchloridTri-amine hydrochlorideTolzaoline bydrochlorideTriethylaminHydrochlorid
RefChem:6324DTXCID2041884209-067-2triethylaminehydrochlorideN,N-diethylethanamine;hydrochlorideEt3N HCltriethylamin hydrochlorideMFCD00012500

데이터베이스 식별자

CAS
554-68-7
PubChem CID
11130
ChEMBL
CHEMBL4446875
UNII
0NX3818GCW
EC Number
209-067-2

물성

구조 계산 물성

극성 표면적
3.2 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
1
회전 가능 결합 수
3
무거운 원자 수
8
형식 전하
0
복잡도
25.7

실험 및 물리화학적 성질

Chemical ClassesNitrogen Compounds -> Amines, Aliphatic
Density1.0689 g/cu cm 21 °C
Color/Form · 2건

Crystals from alcohol

Hexagonal crsystals from alcohol

Solubility · 4건

In water, 1X10+6 mg/L at 25 °C

Soluble in 0.7 parts water

Very soluble in ethanol, chloroform

Soluble in alcohol, chloroform; very slightly soluble in benzene. Practically insoluble in ether

Boiling Point245 °C (sublimes)
DecompositionWhen heated to decomposition it emits toxic vapors of /nitrogen oxides, HCl, chloride anione/
Melting Point260 °C (decomposes)
Vapor Pressure0.0000138 [mmHg]
Physical DescriptionSolid; [HSDB] White crystalline powder; [MSDSonline]
Stability/Shelf LifeStable under recommended storage conditions.

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 21.4% (37 of 173) of reports.

Danger

H314 (11%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 173 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

유해성 정보

Regulatory Information · 3건

Chemical: Ethanamine, N,N-diethyl-, hydrochloride

REACH registered substance: Triethylammonium chloride (EC: 209-067-2)

Triethylammonium chloride: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryEmergency treatment: Triethylamine; [HSDB] An irritant; [MSDSonline] See Triethylamine.
Toxic Combustion ProductsSpecial hazards arising from the substance or mixture: Carbon oxides, nitrogen oxides (NOx), hydrogen chloride gas.
Hazard Classes and CategoriesSkin Corr. 1B (11%)
Shipment Methods and Regulations · 1건

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

화학 및 산업

용도 및 제조

UsesUsed to make quaternary ammonium compounds; [HSDB]
General Manufacturing Information · 2건

Ethanamine, N,N-diethyl-, hydrochloride (1:1): ACTIVE

By using trimethylamine hydrochloride and triethylamine hydrochloride, it was determined that the stimulant action of nicotine in the brain paralleled the nicotine effect in the ganglia of rabbits.

응용 분야 · 1건

용도Triethylamine Hydrochloride is a hydrochloride salt of triethyllamine (T775740). Triethylamine is used as a competing base for the separation of acidic basic and neutral drugs by reverse-phased high-performance liquid chromatography (HPLC). Triethylamine induces visual disturbances (such as foggy vision) in humans, and is also used in industry as a quenching agent in the ozonolysis of alkenes (e.g. (E)-2-Pentene [P227315]). Triethylamine is used in the purification of drugs which are pharmacologically or chemically similar through separation in reverse-phase HPLC (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.

상·하류 제품 정보

상류 원료

트리에틸아민

하류 제품

2-(4-Chloromethylpiperidin-1-yl)pyrimidine-5-carboxamide ,97%트리스(1-아지리디닐)포스핀 황화물2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde

관련 반응

548건
반응 기록 만들기
HRID 4944 반응식
HRID 4944반응물로uspto-grants-1993_09
HRID 5924 반응식
HRID 5924반응물로uspto-grants-1993_09
HRID 11226 반응식
HRID 11226반응물로uspto-grants-2006_08
HRID 11822 반응식
HRID 11822반응물로uspto-grants-2006_08
HRID 18457 반응식
HRID 18457반응물로uspto-grants-2010_06
HRID 22827 반응식
HRID 22827반응물로uspto-grants-2005_02
HRID 28792 반응식
HRID 28792반응물로uspto-grants-2008_09
HRID 38180 반응식
HRID 38180반응물로uspto-grants-2013_09
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화합물 노트

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물리화학적 성질

녹는점
261 °C · 261 °C (dec.)(lit.)
끓는 점
223.18 °C · 223.18°C (rough estimate)
밀도
1.07 · 1.07
굴절률
1.453 · 1.4530 (estimate)
저장 조건
30 °C · Store below +30°C.
용해도
1440 g/L · 1440g/L(20°C)
물리적 상태
결정성 분말
색상
흰색에서 황백색까지
수소이온지수(pH)
5 · 5 (10g/l, H2O, 20℃)
수용성
1440 g/L · 1440g/L(20℃)
Merck
14 · 14,9666
BRN
3906409 · 3906409
InChI
1S/C6H15N.ClH/c1-4-7(5-2)6-3;/h4-6H2,1-3H3;1H
InChIKey
ILWRPSCZWQJDMK-UHFFFAOYSA-N
SMILES
Cl.CCN(CC)CC
EPA
Ethanamine, N,N-diethyl-, hydrochloride (554-68-7)

화학적 성질

White to off-white crystalline powder

Hazardous Reactivities and Incompatibilities
Incompatible materials: Strong oxidizing agents.

안전 및 보호

Fire Fighting Procedures · 2건

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.

Wear self contained breathing apparatus for fire fighting if necessary.

Storage ConditionsKeep container tightly closed in a dry and well-ventilated place. Hygroscopic.
Cleanup Methods · 1건

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Disposal Methods · 2건

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Preventive Measures · 5건

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Do not let product enter drains.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

Personal Protective Equipment (PPE) · 4건

Eye/face protection: Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator. For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

독성 정보

InteractionsIncreases in antibacterial and antifungal properties in vitro, due to the triethylammonium chloride complexation of N-substituted N'-cyano-O-(triphenylstannyl)isoureas, are discussed.
Toxicity Summary · 1건

IDENTIFICATION AND USE: Triethylamine hydrochloride forms hexagonal crystals. It used in preparation of quaternary ammonium compounds. HUMAN EXPOSURE AND TOXICITY: There is no data available. ANIMAL STUDIES: The hemolytic actions of some short-chain alkylamine hydrochlorides were studied. Tertiary salts such as triethylamine hydrochloride produced incomplete hemolysis of dog erythrocytes in vitro, whereas primary salts produced complete hemolysis.

Non-Human Toxicity Excerpts · 1건

/ALTERNATIVE and IN VITRO TESTS/ The hemolytic actions of some short-chain alkylamine hydrochlorides were studied. Tertiary salts such as triethylamine hydrochloride produced incomplete hemolysis of dog erythrocytes in vitro, whereas primary salts produced complete hemolysis. The decreased activity was attributed to the increased bulkiness and lipophilicity of successively alkyl-substituted amine cations. In each group of salts, the hemolytic activity increased with increased alkyl chain length.

Antidote and Emergency Treatment · 3건

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/amines and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related compounds/

안전 데이터

wgk
1
tsca
TSCA listed
rtecs
YE2111500
독성
LDLo scu-mus: 600 mg/kg JPETAB 37,309,29
HS 번호
29211910
risk_code
36/37/38-20/21/22
hazard_code
Xi,Xn
safety_code
26-36-36/37/39-22
기존화학 물질
2015-3-6474
F 고인화성물질
3
Hazard Classifications
Eye Irrit. 2Skin Irrit. 2STOT SE 3
스토리지 클래스
11 - Combustible Solids
유해 물질 데이터
554-68-7(Hazardous Substances Data)
2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxamide
2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride
세포탁심 나트륨
헵테노포스
1-(5-(Hydroxymethyl)pyrimidin-2-yl)piperidin-4-ol
Lisinopril Dihydrate
2-(4-메틸피페라진-1-일)피리미딘-5-카르복실산
2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonitrile
(2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidin-5-yl)methanol
2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxamide
에틸2-(4-메틸피페라진-1-일)피리미딘-5-카르복실레이트
포스아세팀
2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
에틸2-(4-히드록시피페리딘-1-일)피리미딘-5-카르복실레이트
2-(4-메틸피페라진-1-일)피리미딘-5-아민
N,O-비스(트리메틸시릴)아세트아마이드
에틸2-(4-(에톡시카르보닐)피페리딘-1-일)피리미딘-5-카르복실레이트
(2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanol
2-Chloropyrimidine-5-carboxylic acid
2-(4-히드록시피페리딘-1-일)피리미딘-5-카르복실산
에틸2-(4-(히드록시메틸)피페리딘-1-일)피리미딘-5-카르복실레이트
트리아조포스
Atracurium besylate
2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxamide
(2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanamine