Triethylamine hydrochloride → 4-Chloro-8-methoxy-2-(2-trifluoromethylphenyl)-quinazoline

HRID 11822

반응식

HRID 11822 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]([F:22])([F:21])[F:20])[NH:9][C:8]2=O.Cl.C(N(CC)CC)C.O=P(Cl)(Cl)[Cl:34]>>[Cl:34][C:8]1[C:7]2[C:12](=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][CH:6]=2)[N:11]=[C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])[N:9]=1

참가 물질

4

반응물 3

HCID 11130Triethylamine hydrochlorideHCID 24813Phosphorus oxychlorideHCID 1358508318-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one

생성물 1

HCID 219392374-Chloro-8-methoxy-2-(2-trifluoromethylphenyl)-quinazoline수율 89%

실험 절차

Prepared from 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one (1.0 g, 3.12 mmol), triethylamine hydrochloride (472 mg, 3.43 mmol), and POCl3. Purification by flash chromatography afforded a white solid (89% yield). HPLC-Method A, Rt 4.10 min, (98%), MS (m/z) 258.08 (M+H).

후처리

  1. customPurification by flash chromatography

출처 및 근거

ORD 기록
ord-b134537bc4c643eabbfe65a48bec7bec
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098330B2

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