CAS 556-33-2 Glycylglycylglycine (HCID 11161)

개요

Glycyl-glycyl-glycine is a tripeptide in which three glycine units are linked via peptide bonds in a linear sequence. It is a tautomer of a Gly-Gly-Gly zwitterion.

이름 및 식별자

우선 이름: Glycylglycylglycine
IUPAC: 2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetic acid
현지명: 트라이펩타이드-44
영어명: Glycyl-glycyl-glycine
분자식: C6H11N3O4
분자량: 189.17

이름 및 동의어

556-33-2GlycylglycylglycineGlycyl-glycyl-glycineTriglycineGly-Gly-Gly2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetic acidCVK73ZDQ8BNSC-46707CHEBI:63961DTXSID802041402-((2-((2-aminoacetyl)amino)acetyl)amino)acetic acid2-({2-[(2-AMINOACETYL)AMINO]ACETYL}AMINO)ACETIC ACID

이름 더 보기

트라이펩타이드-44Gly-Gly-Gly-OHL-GLYCYL-GLYCYL-GLYCINEH2N-GGG-OHTripeptide-443-mer polyGlyTriglycine,99%

diglycyl-glycineGGG peptideRefChem:143968DTXCID801266312-((2-((2-azaniumylacetyl)amino)acetyl)amino)acetate209-122-0H-Gly-Gly-Gly-OHDiglycylglycine

데이터베이스 식별자

CAS: 556-33-2
PubChem CID: 11161
DTXSID: DTXSID80204140
ChEMBL: CHEMBL54278
ChEBI: CHEBI:63961
UNII: CVK73ZDQ8B
EC Number: 209-122-0
Nikkaji: J43.163J

물성

구조 계산 물성

XLogP: -3.6
극성 표면적: 122 Å²
수소 결합 공여자 수: 4
수소 결합 수용자 수: 5
회전 가능 결합 수: 5
무거운 원자 수: 13
형식 전하: 0
복잡도: 216

실험 및 물리화학적 성질

Chemical ClassesBiological Agents -> Amino Acids and Derivatives

LogP-2.68

Solubility58.5 mg/mL at 25 °C

Melting Point246 °C

Physical Description · 2건

Crystals; [Alfa Aesar MSDS]

Solid

Dissociation Constants · 2건

3.23

7.94

물리화학적 성질

녹는점: 240 · 240-250 °C
끓는 점: 324.41 °C · 324.41°C (rough estimate)
밀도: 1.4204 · 1.4204 (rough estimate)
굴절률: 1.525 · 1.5250 (estimate)
저장 조건: Keep in dark place,Sealed in dry,Room Temperature
용해도: 2 O: · H2O: 0.5 M at 20 °C, 투명, 무색
물리적 상태: 고체
산도 계수 (pKa): 3.225 · 3.225(at 25℃)
색상: 흰색에서 황백색까지
수소이온지수(pH): 4.5 · 4.5-6.0 (25℃, 0.5M in H2O)
수용성: 물(20°C에서 94.6mg/ml), 메탄올(50mg/ml) 및 80% 아세트산(50mg/ml)에 용해됩니다.
Merck: 14 · 14,6579
BRN: 1711130 · 1711130
InChI: 1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)
InChIKey: XKUKSGPZAADMRA-UHFFFAOYSA-N
SMILES: NCC(=O)NCC(=O)NCC(O)=O
NIST: N-(N-Glycylglycyl)glycine(556-33-2)

화학적 성질 · 1건

White prismatic crystals or powder cannot coexist with strong oxidizing agents, aluminum, copper, copper alloy, and nickel. Glycyl-glycyl-glycine has a strong complexing ability and can form stable chelates with different metal ions due to its small molecule size and ability to provide four coordination bonds for metal ions.

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 33.3% (1 of 3) of reports.

Danger

H314 (33.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P271, P272, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazards SummaryMay cause irritation; [Alfa Aesar MSDS]

Hazard Classes and CategoriesSkin Corr. 1B (33.3%)

안전 데이터

wgk: 3
HS 번호: 29241990
F 고인화성물질: 3-10
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

Cellular LocationsCytoplasm

응용 분야

용도Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator and Substrate for tripeptide aminopeptidase.

일반 설명Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.

상·하류 제품 정보

하류 제품

BOC-글리-글리-글리-오

공급사100 곳

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

T&W GROUP021-61551611 13296011611 · [email protected]

Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]

上海将来实业股份有限公司400-0066400 13621662912 · [email protected]

추가 설명

정의ChEBI: Glycyl-glycyl-glycine is a tripeptide in which three glycine units are linked via peptide bonds in a linear sequence. It is a tautomer of a Gly-Gly-Gly zwitterion.