트라이펩타이드-44
트라이펩타이드-44 · GLY-GLY-GLY · H-GLY-GLY-GLY-OH · Gly-Gly-Gly-OH · L-GLYCYL-GLYCYL-GLYCINE · 2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetic acid · H2N-GGG-OH · Tripeptide-44
식별자 및 물리적 특성
| CAS No. | 556-33-2 |
|---|---|
| 분자식 | C6H11N3O4 |
| 평균 분자량 | 189.17 g/mol |
| 단동위원소 질량 | 189.07495583 g/mol |
| SMILES | NCC(=O)NCC(=O)NCC(=O)O |
| InChIKey | XKUKSGPZAADMRA-UHFFFAOYSA-N |
| PubChem CID | 11161 |
| ChEMBL | CHEMBL54278 |
| ChEBI | CHEBI:63961 |
| EC No. | 209-122-0 |
| DTXSID | DTXSID80204140 |
| 현지명 | 트라이펩타이드-44 |
화학 및 물리적 성질
| XLogP | -3.6 |
|---|---|
| 극성 표면적 | 122 |
| 수소 결합 공여자 수 | 4 |
| 수소 결합 수용자 수 | 5 |
| 회전 가능 결합 수 | 5 |
| 무거운 원자 수 | 13 |
| 형식 전하 | 0 |
| 복잡도 | 216 |
| 물질 분류 | Biological Agents -> Amino Acids and Derivatives |
| LogP(분배 계수) | -2.68 |
| 용해도 | 58.5 mg/mL at 25 °CH2O: 0.5 M at 20 °C, 투명, 무색 |
| 녹는점 | 246 °C240-250 °C |
| Physical Description | Crystals[Alfa Aesar MSDS]Solid |
| Dissociation Constants | 3.237.94 |
| 끓는 점 | 324.41°C (rough estimate) |
| 밀도 | 1.4204 (rough estimate) |
| 굴절률 | 1.5250 (estimate) |
| 저장 조건 | Keep in dark place,Sealed in dry,Room Temperature |
| 물리적 상태 | 고체 |
| pKa(산도 계수) | 3.225(at 25℃) |
| 색상 | 흰색에서 황백색까지 |
| pH | 4.5-6.0 (25℃, 0.5M in H2O) |
| 용해도 | 물(20°C에서 94.6mg/ml), 메탄올(50mg/ml) 및 80% 아세트산(50mg/ml)에 용해됩니다. |
| Merck | 14,6579 |
| BRN | 1711130 |
| InChI | 1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13) |
| InChIKey | XKUKSGPZAADMRA-UHFFFAOYSA-N |
| SMILES | NCC(=O)NCC(=O)NCC(O)=O |
| NIST | N-(N-Glycylglycyl)glycine(556-33-2) |
화학적 성질
White prismatic crystals or powder cannot coexist with strong oxidizing agents, aluminum, copper, copper alloy, and nickel. Glycyl-glycyl-glycine has a strong complexing ability and can form stable chelates with different metal ions due to its small molecule size and ability to provide four coordination bonds for metal ions.
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 33.3% (1 of 3) of reports.DangerH314 (33.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P260, P261, P264, P264+P265, P271, P272, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 유해성 요약 | May cause irritation[Alfa Aesar MSDS] |
| Hazard Classes and Categories | Skin Corr. 1B (33.3%) |
| 수질 위해 등급(WGK) | 3 |
| 관세 코드 | 29241990 |
| F 고인화성물질 | 3-10 |
| 저장 분류 | 11 - Combustible Solids |
용도
용도
Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator and Substrate for tripeptide aminopeptidase.
일반 설명
Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.