N-Iodosuccinimide (HCID 120273)

이름 및 식별자

우선 이름: N-Iodosuccinimide
IUPAC: 1-iodopyrrolidine-2,5-dione
현지명: N-아이오도석신이미드
영어명: N-Iodosuccinimide
분자식: C4H4INO2
분자량: 224.98

이름 및 동의어

N-Iodosuccinimide516-12-11-Iodopyrrolidine-2,5-dioneSucciniodimide2,5-Pyrrolidinedione, 1-iodo-1-iodo-2,5-pyrrolidinedione3COS3X3N4PCHEBI:53204DTXSID10199550RefChem:163587DTXCID70122041208-221-6

이름 더 보기

N-아이오도석신이미드IodosuccinimideN-lodosuccinimide1-iodo-5-pyrrolidinedioneN-iododiimideN-Iodouccinimide

N-Iodosuccinimide (NIS)C4H4INO2MFCD00005512Succinimide, N-iodo-NISUNII-3COS3X3N4PEINECS 208-221-62,5-Dioxo-1-iodopyrrolidine

데이터베이스 식별자

CAS: 516-12-1
PubChem CID: 120273
DTXSID: DTXSID10199550
ChEBI: CHEBI:53204
UNII: 3COS3X3N4P
EC Number: 208-221-6
Nikkaji: J6.303G

물성

구조 계산 물성

XLogP: -0.2
극성 표면적: 37.4 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 2
회전 가능 결합 수: 0
무거운 원자 수: 8
형식 전하: 0
복잡도: 129

물리화학적 성질

녹는점: 202 · 202-206 °C(lit.)
끓는 점: 249.6 · 249.6±23.0 °C(Predicted)
밀도: 2 · 2,245 g/cm3
저장 조건: 2 · 2-8°C
용해도: 디옥산, 테트라히드로푸란 및 아세토니트릴에 용해됩니다. 에테르와 사염화탄소에 불용성.
산도 계수 (pKa): -2.57 · -2.57±0.20(Predicted)
물리적 상태: 결정성 분말
색상: 흰색-노란색에서 갈색까지
수용성: 물에서 분해되다
Merck: 14 · 14,5045
BRN: 113917 · 113917
안정성: 수분에 민감한
InChI: 1S/C4H4INO2/c5-6-3(7)1-2-4(6)8/h1-2H2
InChIKey: LQZMLBORDGWNPD-UHFFFAOYSA-N
SMILES: IN1C(=O)CCC1=O

화학적 성질

white-yellow to brown crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 8% (7 of 87) of reports.

Warning

H302 (85.1%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (90.8%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (90.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (87.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 87 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 7 of 87 reports by companies.；There are 17 notifications provided by 80 of 87 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 2건

Status: Active Update: 17-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/25034

2,5-Pyrrolidinedione, 1-iodo-: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 4 (85.1%)；Skin Irrit. 2 (90.8%)；Eye Irrit. 2 (90.8%)；STOT SE 3 (87.4%)

규제 정보

Regulatory Information · 2건

Status: Active Update: 17-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/25034

2,5-Pyrrolidinedione, 1-iodo-: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 3
tsca: No
rtecs: WN2817000
HS 번호: 29251995
risk_code: 22-36/37/38
hazard_code: Xn,Xi
safety_code: 26-36-37/39
위험 등급: IRRITANT
F 고인화성물질: 8-9
위험 참고 사항: Harmful/Keep Cold/Moisture Sensitive
Hazard Classifications: Aquatic Acute 1Aquatic Chronic 1Eye Irrit. 2Muta. 2Skin Irrit. 2Skin Sens. 1B
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

응용 분야

용도N-Iodosuccinimide is a iodo substituted succinimide that is used as an iodinating agent in chemical synthesis.

제조 방법 · 1건

To a solution of 39.2g of succinimide in 1200ml of boiling water was added 51.0g of freshly precipitated silver oxide, the mixture was filtered and the silver salt was allowed to crystallize. Filtration and washing with cold water furnished 45.0g of the silver salt of succinimide suitable for the iodination step. The finely powdered salt (49.5g) was added in portions with stirring to a solution of 50.8g of iodine in 300ml of acetone, the temperature being maintained at 5-10°C. After decolorization (30 min.), the silver iodide was filtered, the solvent was removed under reduced pressure at room temperature and the residue was washed with ether, yielding 43g of N-iodosuccinimide with mp 189-191°C. An analytical sample (85% recovery) was obtained by dissolving in the minimum quantity of hot dioxane and precipitating with carbon tetrachloride; colorless needles, mp 200-201°C. Ref: JACS 75, 3493 (1953)

상·하류 제품 정보

상류 원료

하류 제품

2-클로로-4-니트로페닐-알파-L-푸코피라노사이드 3-요오도-4,5-디메톡시벤즈알데히드 5-Iodo-2,4-dimethoxypyrimidine 3-b]pyridine DBCO-NHS Ester 5-브로모-3-요오도-1H-피라졸로[3,4-b]피리딘 요오도페로센 2-아미노-5-플루오로-3-요오도-벤조산메틸에스테르 2(1H)-Pyridinone, 6-amino-3-iodo-5-nitro-

공급사50 곳

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

宁波君龙新材料有限公司0574 88552216 19032109277 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

추가 설명

정의ChEBI: N-iodosuccinimide is a five-membered cyclic dicarboximide compound having an iodo substituent on the nitrogen atom. It is a dicarboximide and a pyrrolidinone. It derives from a succinimide.

연결된 노트

불러오는 중…

N-아이오도석신이미드

기본 정보