N-Iodosuccinimide → 3-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

HRID 14496

반응식

HRID 14496 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][C:13]([OH:19])=[CH:14][CH:15]=3)[O:10][C:9]=2[CH:20]([CH3:22])[CH3:21])=[CH:4][CH:3]=1.[I:23]N1C(=O)CCC1=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:17](=[O:18])[C:16]3[C:11](=[C:12]([I:23])[C:13]([OH:19])=[CH:14][CH:15]=3)[O:10][C:9]=2[CH:20]([CH3:22])[CH3:21])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 162024513-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one

생성물 1

HCID 597242463-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one (2.3 g, 7.31 mmol) is suspended in dry dichloromethane (140 ml) at room temperature. N-iodosuccinimide (1.73 g, 7.67 mmol) is added, and the mixture is stirred vigorously at room temperature for 30 min. The mixture is diluted with dichloromethane (60 ml), washed with water (3×100 ml) and saturated brine (50 ml), dried (MgSO4) and filtered, and the filtrate is evaporated to give a pale pink solid.

후처리

  1. washwashed with water (3×100 ml) and saturated brine (50 ml)
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customthe filtrate is evaporated
  5. customto give a pale pink solid

출처 및 근거

ORD 기록
ord-d432949c0c7046e1843b5cf1467f7cf1
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732435B2

연결된 노트

불러오는 중…