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안터간

Phenbenzamine

HCID 13751
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
961-71-7
표준 SMILES
CN(C)CCN(Cc1ccccc1)c1ccccc1
InChIKey
CHOBRHHOYQKCOU-UHFFFAOYSA-N
분자식
C17H22N2
평균 분자량
254.37 g/mol
단동위원소 질량
254.17829871

개요

Phenbenzamine is a liquid. (NTP, 1992)

이름 및 식별자

우선 이름
Phenbenzamine
IUPAC
N'-benzyl-N,N-dimethyl-N'-phenylethane-1,2-diamine
현지명
안터간
영어명
Antergan
분자식
C17H22N2
분자량
254.37

이름 및 동의어

PHENBENZAMINEAnterganLergitinBridal961-71-7DimetinaPM245PM 2452339 RPRP 2339Ethylenediamine, N-benzyl-N',N'-dimethyl-N-phenyl-733W48NG2Q
이름 더 보기
안터간Fourneau compound-2339RPbenzyl-(2-dimethylaminoethyl)-phenyl-amineN',N'-dimethyl-N-phenyl-N-(phenylmethyl)ethane-1,2-diamine
PM-245DTXSID3043863N,N-DIMETHYL-N'-PHENYL-N'-PHENYLMETHYL-1,2-ETHANEDIAMINERefChem:172649DTXCID1023863N-Benzyl-N',N'-dimethyl-N-phenylethylenediamineN'-benzyl-N,N-dimethyl-N'-phenylethane-1,2-diamine1,2-ETHANEDIAMINE, N1,N1-DIMETHYL-N2-PHENYL-N2-(PHENYLMETHYL)-

데이터베이스 식별자

CAS
961-71-7
PubChem CID
13751
DTXSID
DTXSID3043863
ChEMBL
CHEMBL157118
ChEBI
CHEBI:135041
UNII
733W48NG2Q
Nikkaji
J7.194C

물성

구조 계산 물성

XLogP
3.7
극성 표면적
6.5 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
2
회전 가능 결합 수
6
무거운 원자 수
19
형식 전하
0
복잡도
227

실험 및 물리화학적 성질

Density1.019 (NTP, 1992) - Denser than water; will sink
Boiling Point354 to 356 °F at 7 mmHg (NTP, 1992)
Physical DescriptionPhenbenzamine is a liquid. (NTP, 1992)

물리화학적 성질

끓는 점
387.59 °C · 387.59°C (rough estimate)
밀도
1.016 · 1.0160
굴절률
1.5794 · 1.5794
색상
담황색 오일
EPA
Phenbenzamine (961-71-7)

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

유해성 정보

Health HazardsACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. (NTP, 1992)
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity Profile · 1건

PHENBENZAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Air and Water ReactionsNo rapid reaction with air. No rapid reaction with water.

안전 및 보호

Fire Fighting · 1건

This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)

First Aid · 1건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1건

SMALL SPILLS AND LEAKAGE: Dampen spilled material with toluene to avoid dust, then transfer material to a suitable container. Use absorbent paper dampened with toluene to pick up remaining material. Wash surfaces well with soap and water. Seal all waste in vapor-tight plastic bags for eventual disposal.

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 5건

Agents, usually topical, that relieve itching (pruritus).

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Metabolite PathwaysPhenbenzamine H1-Antihistamine Action

응용 분야

역사In 1942 phenbenzamine (Antergan), C17H22N2, was the first antihistamine to be successfully used in humans.

일반 설명Liquid.

공급사1 곳

Lanospharma Laboratories Co.,Ltd13440048448 · [email protected]

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이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
Personal Protective Equipment (PPE) · 1건

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

안전 데이터

독성
LDLo ipr-rat: 120 mg/kg BJPCAL 11,1,56