2-Amino-5-methylpyridine

HCID 15348CAS 1603-41-4
부분 구조 검색유사 구조 찾기

기본 정보

표준 SMILES
Cc1ccc(N)nc1
InChIKey
CMBSSVKZOPZBKW-UHFFFAOYSA-N
분자식
C6H8N2
평균 분자량
108.14 g/mol
단동위원소 질량
108.06874826

개요

structure in first source

이름 및 식별자

우선 이름
2-Amino-5-methylpyridine
IUPAC
5-methylpyridin-2-amine
영어명
2-Amino-5-methylpyridine
분자식
C6H8N2
분자량
108.14

이름 및 동의어

2-Amino-5-methylpyridine1603-41-42-Pyridinamine, 5-methyl-6-Amino-3-methylpyridine5-Methyl-2-aminopyridineDTXSID40292208UM54T43WTNSC-1489NSC-96444DTXCID909220RefChem:540222216-503-5
이름 더 보기
Perfenidone Impurity 2Pyridine, 2-amino-5-methylNSC 1489NSC 96444AKOS 91156Compound Fr142936-amino-3-picolin
5-METHYLPYRIDIN-2-AMINE6-Amino-3-picoline2-AMINO-5-PICOLINE5-Methyl-2-pyridinamine3-Picoline, 6-amino-5-Methyl-2-pyridylamine5-methylpyridin-2-ylaminePirfenidone EP Impurity A

데이터베이스 식별자

CAS
1603-41-4
PubChem CID
15348
DTXSID
DTXSID4029220
ChEMBL
CHEMBL61990
UNII
8UM54T43WT
EC Number
216-503-5
Nikkaji
J31.383A

물성

구조 계산 물성

XLogP
1
극성 표면적
38.9 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
0
무거운 원자 수
8

실험 및 물리화학적 성질

SpringerMaterials PropertiesNuclear quadrupole resonance spectroscopy
LogP1.02

물리화학적 성질

녹는점
76 · 76-77 °C(lit.)
끓는 점
227 °C · 227 °C(lit.)
밀도
227 · 227
증기압
3.706 Pa · 3.706Pa at 25℃
굴절률
1 · 1,524-1,528
인화점
118 °C · 118°C

화학적 성질

light yellow crystalline flakes

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H301 (98.3%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 60 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

Status: Active Update: 15-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/20106

2-Amino-5-methylpyridine: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 3 (98.3%)

안전 데이터

wgk
3
tsca
TSCA listed
rtecs
TJ5141000
ridadr
UN 2811 6.1/PG 2
독성
LD50 orl-rat: 200 mg/kg 85JCAE -,841,86
HS 번호
29333999

화학 및 산업

용도 및 제조

General Manufacturing Information2-Pyridinamine, 5-methyl-: ACTIVE
응용 분야 · 1건

용도2-Amino-5-methylpyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of Fluazuron, which is a pesticide, and for commercial purposes.

제조 방법

생산 방법2-Amino-5-methylpyridine is obtained when 3-methyl-pyridine is reacted with sodium amide in an inert diluent at elevated temperature and elevated pressure (compare U.S. Pat. No. 4,386,209).

상·하류 제품 정보

하류 제품

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海泰矶林实业有限公司02150630626 17717886015 · [email protected]
杭州倍生元生物科技有限公司15700194842 15700194842

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