2-(Trimethylsilyl)ethanol (HCID 18013)

이름 및 식별자

우선 이름: 2-(Trimethylsilyl)ethanol
IUPAC: 2-trimethylsilylethanol
영어명: 2-(Trimethylsilyl)ethanol
분자식: C5H14OSi
분자량: 118.25

이름 및 동의어

2-(Trimethylsilyl)ethanol2916-68-9ETHANOL, 2-(TRIMETHYLSILYL)-GF24TDM0VONSC-96784DTXSID80183421RefChem:849112-TMSEDTXCID90105912220-844-5(2-Hydroxyethyl)trimethylsilane2-trimethylsilylethanol

이름 더 보기

trimethylsilylethanolDK254DK717DKSI0330.825 g/MLDKFELEX01842-(TrimethyLTIMTEC-BB SBB009030

2-(trimethylsilyl)ethan-1-ol2-HYDROXYETHYLTRIMETHYLSILANESilane, (2-hydroxyethyl)trimethyl-C5H14OSi2-(trimethylsily)ethanolMFCD000028252-Trimethylsilanyl-ethanol2-(trimethylsilyl)-ethanol

데이터베이스 식별자

CAS: 2916-68-9
PubChem CID: 18013
DTXSID: DTXSID80183421
ChEMBL: CHEMBL25482
UNII: GF24TDM0VO
EC Number: 220-844-5
Nikkaji: J49.849A

물성

구조 계산 물성

극성 표면적: 20.2 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 1
회전 가능 결합 수: 2
무거운 원자 수: 7
형식 전하: 0
복잡도: 46.5

실험 및 물리화학적 성질

SpringerMaterials Properties29Si nuclear magnetic resonance spectrum

물리화학적 성질

끓는 점: 71 · 71-73 °C35 mm Hg(lit.)
밀도: 0.825 g/mL · 0.825 g/mL at 25 °C(lit.)
굴절률: 20 · n20/D 1.423(lit.)
인화점: 123 °F · 123 °F
저장 조건: 2 · Sealed in dry,2-8°C
용해도: 클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨)
산도 계수 (pKa): 15.38 · 15.38±0.10(Predicted)
물리적 상태: 액체
색상: 무색의
Specific Gravity: 0.825 · 0.825
수용성: 녹는
BRN: 1732034 · 1732034
안정성: 흡습성
InChI: 1S/C5H14OSi/c1-7(2,3)5-4-6/h6H,4-5H2,1-3H3
InChIKey: ZNGINKJHQQQORD-UHFFFAOYSA-N
SMILES: C[Si](C)(C)CCO
NIST: -2 · Trimethyl-2-hydroxyethylsilane(2916-68-9)

화학적 성질

CLEAR COLOURLESS LIQUID

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 57 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information2-(Trimethylsilyl)-ethanol: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesFlam. Liq. 3 (100%)

안전 데이터

wgk: 3
tsca: No
rtecs: KM5480000
ridadr: UN 1987 3/PG 3
독성: mouse,LD50,intraperitoneal,1122mg/kg (1122mg/kg),Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 229, Pg. 1011, 1976.
HS 번호: 29310095
risk_code: 10-36/37/38
hazard_code: Xi,F
safety_code: 16-37/39-26-24/25
포장분류: III
위험 등급: 3
위험 참고 사항: Flammable
Hazard Classifications: Flam. Liq. 3
스토리지 클래스: 3 - Flammable liquids

화학 및 산업

응용 분야 · 1건

용도2-(Trimethylsilyl)ethanol is a protecting reagent for carboxyl, phosphoryl, hydroxyl, and amino groups. It participates in the reactions of Phenol and Acid Protection, Alcohol Protection, Hemiacetal Protection, Amine Protection, Enol Ether Synthesis, Carbohydrate Chemistry etc.

제조 방법 · 1건

Three methods of preparation have been reported: (a) from the treatment of ethyl bromoacetate with zinc followed by the reaction with chlorotrimethylsilane1 and subsequent reduction of the resultant ethyl trimethylsilylacetate with lithium aluminum hydride2,3 or borane¨Ctetrahydrofuran(eq 1); (b) from the hydroboration/oxidation or oxymercuration/demercuration of vinyltrimethylsilane (eq 2); and (c)most conveniently, by the reaction of the Grignard reagent formed from (chloromethyl)trimethylsilane with paraformaldehyde (eq 3).