6,7-Dimethoxy-3-phenylquinoxaline
1296 · AG 1296 · A 1296 · AG-1296 · TYRPHOSTIN AG 1296 · Tyrphostin AG 1296 ，S8024 · TYRPHOSTIN AG 1296 USP/EP/BP · Tyrphostin AG 1296 (AG 1296)
식별자 및 물리적 특성
| CAS No. | 146535-11-7 |
|---|---|
| 분자식 | C16H14N2O2 |
| 평균 분자량 | 266.29 g/mol |
| 단동위원소 질량 | 266.10552769 g/mol |
| SMILES | COc1cc2ncc(-c3ccccc3)nc2cc1OC |
| InChIKey | QNOXYUNHIGOWNY-UHFFFAOYSA-N |
| PubChem CID | 2049 |
| ChEMBL | CHEMBL71191 |
| ChEBI | CHEBI:93335 |
| DTXSID | DTXSID70163393 |
화학 및 물리적 성질
| XLogP | 2.8 |
|---|---|
| 극성 표면적 | 44.2 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 3 |
| 무거운 원자 수 | 20 |
| 형식 전하 | 0 |
| 복잡도 | 307 |
| 끓는 점 | 420.2±40.0 °C(Predicted) |
| 밀도 | 1.192±0.06 g/cm3(Predicted) |
| 저장 조건 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| 용해도 | DMSO에 용해됩니다. |
| pKa(산도 계수) | 0.48±0.30(Predicted) |
| 물리적 상태 | 흰색 고체 |
| 색상 | 노란색 |
| 안정성 | 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다. |
| InChI | 1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3 |
| InChIKey | QNOXYUNHIGOWNY-UHFFFAOYSA-N |
안전 및 규제
| 수질 위해 등급(WGK) | 3 |
|---|---|
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC50 value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC50 values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.
용도
Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.