Amfenac

HCID 2136

기본 정보

CAS
51579-82-9
표준 SMILES
Nc1c(CC(=O)O)cccc1C(=O)c1ccccc1
InChIKey
SOYCMDCMZDHQFP-UHFFFAOYSA-N
분자식
C15H13NO3
평균 분자량
255.27 g/mol
단동위원소 질량
255.08954328

개요

Amfenac is an oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a cyclooxygenase 2 inhibitor and a cyclooxygenase 1 inhibitor. It is a member of benzophenones, an amino acid, an oxo monocarboxylic acid, a substituted aniline and a primary amino compound. It is a conjugate acid of an amfenac(1-).

이름 및 식별자

우선 이름
Amfenac
IUPAC
2-(2-amino-3-benzoylphenyl)acetic acid
영어명
amfenac
분자식
C15H13NO3
분자량
255.27

이름 및 동의어

Amfenac51579-82-9Amfenaco(2-Amino-3-benzoylphenyl)acetic acidAmfenacum(2-Amino-3-benzoylphenyl)essigsaeureNSC-309467CHEBI:7591528O5C1J38ADTXSID901995332-(2-amino-3-(benzoyl)phenyl)acetic acid2-[2-amino-3-(benzoyl)phenyl]acetic acid
이름 더 보기
SOYCMDCMZDHQFP-UHFFFAOYSA-NNepafenac Impurity 5(Amfenac)2-Amino-3-benzoylbenzeneacetic acidBenzeneacetic acid, 2-amino-3-benzoyl-Amfenac D5Q: What is Amfenac D5 Q: What is the CAS Number of Amfenac D5 Q: What is the storage condition of Amfenac D5 Q: What are the applications of Amfenac D5
RefChem:111914DTXCID501220242-Amino-3-benzoylbenzeneacetic acid, monosodium salt, monohydrate2-(2-amino-3-benzoylphenyl)acetic acidAmfenac (INN)AMFENAC [INN]NSC 309467Amfenac sodium salt hydrate

데이터베이스 식별자

CAS
51579-82-9
PubChem CID
2136
DTXSID
DTXSID90199533
ChEMBL
CHEMBL25146
ChEBI
CHEBI:75915
UNII
28O5C1J38A
Nikkaji
J11.225I

물성

구조 계산 물성

XLogP
2.6
극성 표면적
80.4 Ų
수소 결합 공여자 수
2
수소 결합 수용자 수
4
회전 가능 결합 수
4
무거운 원자 수
19

물리화학적 성질

녹는점
121 · 121-123° (dec)
끓는 점
398.5 °C · 398.5°C (rough estimate)
밀도
1.1654 · 1.1654 (rough estimate)
굴절률
1.55 · 1.5500 (estimate)

안전 및 규제

안전 데이터

독성
LD50 in mice, rats (mg/kg): 615, 311 orally (Sancilio)

화학 및 산업

약리 정보

Mechanism of ActionAmfenac mediates its anti-inflammatory effects by inhibiting cyclo-oxygenases.

응용 분야

용도Anti-inflammatory.

상·하류 제품 정보

공급사13 곳

深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
赛纳斯特化学(欢迎点击联系)021-60343070
常州翔龙医药科技有限公司18915873328 18915873328 · [email protected]
深圳振强药物研发有限公司+86-0755-66853366 +86-13670046396 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
추가 설명 · 1건

정의ChEBI: An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used fo the treatment of pain and inflammation following cataract surgery.

관련 반응

19건

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