Sodium Hydroxide → Amfenac

HRID 442545

반응식

HRID 442545 반응식
[C:1]([C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[NH:16][C:15](=[O:18])[CH2:14]2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:19].[Na+]>>[NH2:16][C:17]1[C:9]([C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:10][CH:11]=[CH:12][C:13]=1[CH2:14][C:15]([OH:18])=[O:19]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 1709837-Benzoyl-2-oxindole

생성물 1

HCID 2136Amfenac

실험 절차

A mixture of 1.0 g. (0.004 mole) of 7-benzoylindolin-2-one was added to 30 ml. of 3N sodium hydroxide and the basic solution was refluxed for 45 minutes under nitrogen. The mixture was filtered and the filtrate was neutralized with glacial acetic acid. The precipitate was filtered off, washed with water and dried. The material melted at 122° C. (dec.). The yield was 0.8 g. (72%).

후처리

  1. additionA mixture of 1.0 g
  2. filtrationThe mixture was filtered
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-d13b5b9f6e454e5198c7607b2243951d
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045576

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