기본 정보
- CAS
99464-64-9- 표준 SMILES
CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21- InChIKey
LSNWBKACGXCGAJ-UHFFFAOYSA-N- 분자식
- C20H21N3O7S
- 평균 분자량
- 447.5 g/mol
- 단동위원소 질량
- 447.11002119
개요
Ampiroxicam is a benzothiazine that is the 1-[(ethoxycarbonyl)oxy]ethyl ether of piroxicam. A prodrug for piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis. It has a role as a non-steroidal anti-inflammatory drug, an analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antirheumatic drug and a prodrug. It is a monocarboxylic acid amide, a sulfonamide, an aminopyridine, a benzothiazine, an etabonate ester and an acetal. It is functionally related to a piroxicam.
이름 및 식별자
- 우선 이름
- Ampiroxicam
- IUPAC
- ethyl 1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ6,2-benzothiazin-4-yl]oxy]ethyl carbonate
- 현지명
- 암피록시캠
- 영어명
- Ampiroxicam
- 분자식
- C20H21N3O7S
- 분자량
- 447.46
이름 및 동의어
ampiroxicam99464-64-9FlucamAmpiroxicamumCP 65703CP-65703DTXSID60464740PV32JZB1JNSC-759807CHEBI:31210CP-65,703DTXCID4026474
이름 더 보기
암피록시캠NasilAmpiroamAmpiroxicam 98%Ampiroxicam(CP 65703)Ampiroxicam USP/EP/BPAmpiroxicam - Bio-X ?99464-64-9 Ampiroxicam
(+-)-4-(1-Hydroxyethoxy)-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide ethyl carbonate (ester), 1,1-dioxideRefChem:557922807-877-6Ethyl (1RS)-1-((2-methyl-1,1-dioxido-3-((pyridin-2-ylamino)carbonyl)-2H-1,2-benzothiazin-4-yl)oxy)ethyl carbonateAmpiroxicam [INN:BAN:JAN]AMPIROXICAM [MI]AMPIROXICAM [WHO-DD]ethyl (1-((2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2H-benzo[e][1,2]thiazin-4-yl)oxy)ethyl) carbonate
데이터베이스 식별자
- CAS
99464-64-9- PubChem CID
- 2176
- DTXSID
DTXSID6046474- ChEMBL
CHEMBL1566249- ChEBI
CHEBI:31210
물성
구조 계산 물성
- XLogP
- 4
- 극성 표면적
- 133 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 31
- 형식 전하
- 0
- 복잡도
- 808
물리화학적 성질
- 녹는점
- 159 · 159-161C
- 밀도
- 1.44 · 1.44±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · Sealed in dry,2-8°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 12.74 · 12.74±0.20(Predicted)
- 색상
- 흰색에서 황백색까지
화학적 성질
White Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (100%)
독성 정보
Drug Induced Liver Injury
Drug-Induced Liver Injury Severity and Toxicity (DILIst)
Ampiroxicam
DILI Positive
DOI:10.1016/j.drudis.2019.09.022
안전 데이터
- 독성
- LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima)
화학 및 산업
응용 분야
개요Ampiroxicam is a once-daily non-steroidal anti-inflammatory drug (NSAID) introduced in Japan. As a non-acidic ether carbonate prodrug of the widely used antiinflammatory agent, piroxicam, ampiroxicam is similar or more potent than piroxicam in suppressing carrageenan edema, ultraviolet erythema, traumatic edema, capillary permeability, acetic acid writhing, yeast algesia and yeast hyperthermia in many animals. Eioavailability studies in man show undetectable plasma levels of ampiroxicam indicating 100% conversion to piroxicam during absorption process. Ampiroxicam has been reported to have fewer side effects on the gastric mucosa than piroxicam.
용도Prodrug of Piroxicam. Anti-inflammatory.
상·하류 제품 정보
상류 원료
공급사86 곳
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
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