Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
뷰틸 시아노아크릴산 염
뷰틸시아노아크릴산염 · 문서화하다 · n-Butyl Cyanoacrylate · BUTYLCYANOACRYLATE · n-Butyl 2-Cyanoacrylate · NBCA n-butyl cyanoacrylate tissue adhesive · Indermil · Tisuacryl
식별자 및 물리적 특성
| CAS No. | 25154-80-7 |
|---|---|
| 분자식 | C8H11NO2 |
| 평균 분자량 | 153.18 g/mol |
| 단동위원소 질량 | 153.07897859 g/mol |
| SMILES | C=C(C#N)C(=O)OCCCC |
| InChIKey | JJJFUHOGVZWXNQ-UHFFFAOYSA-N |
| PubChem CID | 23087 |
| ChEMBL | CHEMBL2104251 |
| ChEBI | CHEBI:134778 |
| EC No. | 229-552-2 |
| DTXSID | DTXSID5064417 |
| 현지명 | 뷰틸 시아노아크릴산 염 |
화학 및 물리적 성질
| XLogP | 2.4 |
|---|---|
| 극성 표면적 | 50.1 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 5 |
| 무거운 원자 수 | 11 |
| 형식 전하 | 0 |
| 복잡도 | 199 |
| 의약품 | Pharmaceuticals -> Listed in ZINC15 |
| 끓는 점 | bp1.8 68° |
| 밀도 | d20 0.989 |
| 증기압 | 1.3hPa at 20℃ |
| 굴절률 | n20D 1.4424nD25 1.4410 |
| 인화점 | closed cup: >176°F (>80°C) |
| 저장 조건 | under inert gas (nitrogen or Argon) at 2-8°C |
| 용해도 | 클로로포름(적게), 에틸아세테이트(약간)에 용해됨 |
| 물리적 상태 | 기름 |
| 색상 | 무색 |
| InChI | InChI=1S/C8H11NO2/c1-3-4-5-11-8(10)7(2)6-9/h2-5H2,1H3 |
| InChIKey | JJJFUHOGVZWXNQ-UHFFFAOYSA-N |
| SMILES | C(OCCCC)(=O)C(C#N)=C |
| LogP(분배 계수) | 1.29 at 25℃ and pH7 |
| 표면장력 | 34.28mN/m at 1g/L and 20℃ |
| EPA | Butyl 2-cyanoacrylate (6606-65-1) |
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 100% (19 of 19) of all reports.Not ClassifiedAggregated GHS information provided per 19 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|---|
| 규제 정보 | Chemical: 2-Propenoic acid, 2-cyano-, butyl esterREACH registered substance: Enbucrilate (EC: 229-552-2)n-Butyl cyanoacrylate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Hazard Classes and Categories | Not Classified |
| Treatment | Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite, which release the cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that combines serum cyanide with thiosulfate, producing comparatively harmless thiocyanate. Oxygen therapy can also be administered. (L97) |
| 건강 영향 | Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L96, L97) |
| 노출 경로 | Oral (L96)inhalation (L96)dermal (L96) |
| 독성 요약 | Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxic cyanide ions or hydrogen cyanide. Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97) |
| Signs and Symptoms | Cyanide poisoning is identified by rapid, deep breathing and shortness of breath, general weakness, giddiness, headaches, vertigo, confusion, convulsions/seizures and eventually loss of consciousness. (L96, L97) |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| TSCA 등재 상태 | TSCA listed |
| 기존화학 물질 | KE-09115 |
용도
용도
Enbucrilate is bacteriostatic and its use is usually painless. It is used as an adhesive for lacerations of the skin, and in the treatment of bleeding from vascular structures.