기본 정보
- CAS
27164-46-1- 표준 SMILES
Cc1nnc(SCC2=C(C(=O)[O-])N3C(=O)[C@@H](NC(=O)Cn4cnnn4)[C@H]3SC2)s1.[Na+]- InChIKey
FLKYBGKDCCEQQM-WYUVZMMLSA-M- 분자식
- C14H13N8NaO4S3
- 평균 분자량
- 476.5 g/mol
- 단동위원소 질량
- 476.01195818
개요
Cefazolin sodium is a cephalosporin organic sodium salt having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups. It contains a cefazolin(1-).
이름 및 식별자
- 우선 이름
- Cefazolin Sodium
- IUPAC
- sodium (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- 현지명
- 세프타졸린 나트륨
- 영어명
- Cefazolin sodium salt
- 분자식
- C14H15N8NaO4S3
- 분자량
- 478.5
이름 및 동의어
CEFAZOLIN SODIUM27164-46-1Cefazolin sodium saltCefazoline sodiumTotacefCefacidalCefamedinGramaxinZolicefCefazilKefzolAncef
이름 더 보기
세프타졸린나트륨세프타졸린나트륨(CEFAZOLINSODIUM)Cefazolin sodium sterileCefazoline sodium sterilesodium 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.046083AtirinAzolin
Sodium cefazolinSodium cephazolinMonosodium cefazolinCephazolin SodiumCefazolin injectionSK&F 41558CEFAZOLIN AND DEXTROSEANCEF IN PLASTIC CONTAINER
데이터베이스 식별자
- CAS
27164-46-1- PubChem CID
- 23675322
- DTXSID
DTXSID901015786- ChEMBL
CHEMBL1200523- ChEBI
CHEBI:3483- UNII
- P380M0454Z
- EC Number
- 248-278-4
물성
구조 계산 물성
- 극성 표면적
- 238 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 12
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 746
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section183.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
물리화학적 성질
- 녹는점
- 190 °C · 190 °C
- 굴절률
- 20 ° · 20 ° (C=10, H2O)
- 저장 조건
- 2 · Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- 2 O: · H2O: 50 mg/mL, 투명, 무색
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 황백색까지
- Merck
- 14 · 14,1917
- BRN
- 3585038 · 3585038
- 안정성
- 안정적이지만 열에 민감할 수 있으므로 서늘한 곳에 보관하세요. 빛에 노출되면 변색될 수 있으므로 어두운 곳에 보관하세요. 강한 산화제와 호환되지 않습니다.
- InChIKey
- LJIOGPYKTPCRAP-MVOALHSDNA-N
- SMILES
- C(C1=C(CS[C@]2([H])[C@H](NC(=O)CN3N=NN=C3)C(=O)N12)CSC1=NN=C(C)S1)(=O)O.[NaH] |&1:5,7,r|
- LogP
- 1.133 · 1.133 (est)
화학적 성질
White to off-white powder
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H317 (98.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 62 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Other Safety InformationIMAP assessments - 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-, monosodium salt, (6R-trans)-: Environment tier I assessment
Hazard Classes and CategoriesSkin Sens. 1 (98.4%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Cefazolin sodium
vLess-DILI-concern
3
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- 2
- rtecs
- XI0390000
- 독성
- LD50 in mice, rats (mg/kg): 3.9, 3.18 i.v.; 6.2, 7.4 i.p. (Birkhead)
- HS 번호
- 29349990
- risk_code
- 42/43-36/37/38-20/21/22
- hazard_code
- Xn,Xi
- safety_code
- 22-36/37-36-26
- 기존화학 물질
- KE-25358
- Hazard Classifications
- Resp. Sens. 1Skin Sens. 1
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
FDA Pharmacological Classification
CEFAZOLIN SODIUM
Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
응용 분야
개요Cefazolin was synthesized by Fujisawa Pharmaceutical Co. in 1969. It was the first of the cephem antibiotics to introduce a thiadiazolylthiomethyl group at the 3 position and a tetrazole group at the 7 position in the side chain. Cefazolin is a parenteral cephem antibiotic showing better activity against gramnegative bacteria than cephalothin or cephaloridine. Its bactericidal activity, tissue distribution, and urinary excretion are excellent and it has wide clinical use.
용도Semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. An antibacterial
상·하류 제품 정보
상류 원료
공급사100 곳
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
HubeiwidelychemicaltechnologyCo.,Ltd18627774460 · [email protected]
湖北金梭生物科技有限公司00123456789 · [email protected]
陕西帕尼尔生物科技有限公司029-84385017; +8613259417953 · [email protected]
河北展药生物科技有限公司15369953316 +8615369953316 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
上海弘顺生物科技有限公司15901914505 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
上海晶抗生物工程有限公司021-54721350 13524668266 · [email protected]
大连美仑生物技术有限公司0411-62910999 13889544652 · [email protected]
추가 설명
정의ChEBI: A cephalosporin organic sodium salt having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups.
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