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Sodium Bicarbonate → Cefazolin Sodium

HRID 28025
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HRID 28025 반응식
[SH:1][C:2]1[S:6][C:5]([CH3:7])=[N:4][N:3]=1.C(=O)([O-])O.[Na+:12].[N:13]1([CH2:18][C:19]([NH:21][C@@H:22]2[C:51](=[O:52])[N:24]3[C:25]([C:48]([OH:50])=[O:49])=[C:26]([CH2:29]OC(=O)C4C=CC=CC=4S(=O)(=O)NC(OCC)=O)[CH2:27][S:28][C@H:23]23)=[O:20])[CH:17]=[N:16][N:15]=[N:14]1>P([O-])([O-])([O-])=O>[N:13]1([CH2:18][C:19]([NH:21][C@@H:22]2[C:51](=[O:52])[N:24]3[C:25]([C:48]([O-:50])=[O:49])=[C:26]([CH2:29][S:1][C:2]4[S:6][C:5]([CH3:7])=[N:4][N:3]=4)[CH2:27][S:28][C@H:23]23)=[O:20])[CH:17]=[N:16][N:15]=[N:14]1.[Na+:12]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 705840957beta-(1H-tetrazol-1-yl)acetamido-3-[2-(N-carboethoxysulfamoyl)benzoyloxy]methyl-3-cephem-4-carboxylic acidHCID 178434161HCID 178434161, 화합물

생성물 1

HCID 23675322Cefazolin Sodium

시약·촉매·용매 1

HCID 1061Phosphate용매

실험 절차

In a phosphate buffer solution of pH 6.4(3 ml) are dissolved 5-mercapto-2-methyl-1,3,4-thiadiazole (79 mg), sodium hydrogen carbonate (92 mg) and 7β-(1H-tetrazol-1-yl)acetamido-3-[2-(N-carboethoxysulfamoyl)benzoyloxy]methyl-3-cephem-4-carboxylic acid (298 mg) and the resultant solution is heated at 60° C. for one hour. Then, the mixture is concentrated and the residue is subjected to column chromatography on Sephadex LH-20, elution being carried out with water. The fractions containing the desired product are pooled and lyophilized. The procedure provides sodium 7β-(1H-tetrazol-1-yl)acetamido-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate. This product is in good agreement with the authentic sample in NMR spectrum.

후처리

  1. concentrationThen, the mixture is concentrated
  2. washthe residue is subjected to column chromatography on Sephadex LH-20, elution
  3. additionThe fractions containing the desired product

출처 및 근거

ORD 기록
ord-e77bd40c809c42ecbc85079b60f8f7b8
출처 데이터셋
uspto-grants-1980_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04224441

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