레바미졸

레바미졸 · LEVAMISOLE BASE · (S)-6-phenyl-2,3,5,6-tetrahydroiMidazo[2,1-b]thiazole · lepuron · levomysol · Ketrax · LEVAMISOLE · l-tetramisole

https://huagongshe.com/ko/chemical/26879

식별자 및 물리적 특성

CAS No.	14769-73-4
분자식	C11H12N2S
평균 분자량	204.29 g/mol
단동위원소 질량	204.07211956 g/mol
SMILES	c1ccc([C@H]2CN3CCSC3=N2)cc1
InChIKey	HLFSDGLLUJUHTE-SNVBAGLBSA-N
PubChem CID	26879
ChEMBL	CHEMBL1454
ChEBI	CHEBI:6432
EC No.	238-836-5
DTXSID	DTXSID4023206
현지명	레바미졸

화학 및 물리적 성질

XLogP	1.8
극성 표면적	40.9
수소 결합 공여자 수	0
수소 결합 수용자 수	2
회전 가능 결합 수	1
무거운 원자 수	14
형식 전하	0
복잡도	246
녹는점	60-61.5°
끓는 점	344.4±45.0 °C(Predicted)
밀도	1.32±0.1 g/cm3(Predicted)
저장 조건	Sealed in dry,2-8°C
용해도	클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태	고체
pKa(산도 계수)	10.00±0.40(Predicted)
색상	황백색에서 연한 노란색
InChI	InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
InChIKey	HLFSDGLLUJUHTE-SNVBAGLBSA-N
SMILES	S1CCN2C[C@H](C3=CC=CC=C3)N=C12
EPA	Levamisole (14769-73-4)

안전 및 규제

기존화학 물질	97-3-152

용도

Levamisole is used for initial and secondary immunodeficient conditions, autoimmune diseases, chronic and reoccurring infections, large intestine adenocarcinoma, helmintosis, and rheumatoid arthritis. Synonyms of this drug are decaris, tetramizole, and others.Levimasole is also a drug of choice for ascardiasis. Numerous investigations show that a single dose of levamisole heals from 90 to 100% of patients with ascardiasis, in particular those infected with A. duodenale. It is less effective against ancylostomiasis and strongyloidiasis. However, it is not effective against N. americanus. It seems likely that it has a gangliostimulating effect on parasite tissues in both the parasympathetic and sympathetic regions. Moreover, it is presumed that this drug has an immunomodulatory effect on the host organism. Synonyms of this drug are decaris, solacil, ergamisol, tramisol, immunol, and others.