레바미졸

Levamisole

HCID 26879CAS 14769-73-4

기본 정보

표준 SMILES
c1ccc([C@H]2CN3CCSC3=N2)cc1
InChIKey
HLFSDGLLUJUHTE-SNVBAGLBSA-N
분자식
C11H12N2S
평균 분자량
204.29 g/mol
단동위원소 질량
204.07211956

이름 및 식별자

우선 이름
Levamisole
IUPAC
(6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
현지명
레바미졸
영어명
Levamisole
분자식
C11H12N2S
분자량
204.29

이름 및 동의어

levamisole14769-73-4LevamisolKetraxL-TetramisoleLepuronLEVOMYSOLWormicid(S)-(-)-LevamisoleLevamisolum(-)-Tetramisole(6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
이름 더 보기
레바미졸LEVAMISOLE BASE(S)-6-phenyl-2,3,5,6-tetrahydroiMidazo[2,1-b]thiazole(?)-LevamisoleLevamisole WickrLevamisole powder
Tetramisole, (s)-Totalon(6S)-6-phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazoleImidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-(S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazoleImidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (S)-CHEBI:64322880D3468G

데이터베이스 식별자

CAS
14769-73-4
PubChem CID
26879
DTXSID
DTXSID4023206
ChEMBL
CHEMBL1454
ChEBI
CHEBI:6432
UNII
2880D3468G
EC Number
238-836-5
Nikkaji
J8.518I

물성

구조 계산 물성

XLogP
1.8
극성 표면적
40.9 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
2
회전 가능 결합 수
1
무거운 원자 수
14

물리화학적 성질

녹는점
60 · 60-61.5°
끓는 점
344.4 · 344.4±45.0 °C(Predicted)
밀도
1.32 · 1.32±0.1 g/cm3(Predicted)
저장 조건
2 · Sealed in dry,2-8°C
용해도
클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체

안전 및 규제

안전 데이터

기존화학 물질
97-3-152

화학 및 산업

응용 분야 · 1건

용도Levamisole is used for initial and secondary immunodeficient conditions, autoimmune diseases, chronic and reoccurring infections, large intestine adenocarcinoma, helmintosis, and rheumatoid arthritis. Synonyms of this drug are decaris, tetramizole, and others.Levimasole is also a drug of choice for ascardiasis. Numerous investigations show that a single dose of levamisole heals from 90 to 100% of patients with ascardiasis, in particular those infected with A. duodenale. It is less effective against ancylostomiasis and strongyloidiasis. However, it is not effective against N. americanus. It seems likely that it has a gangliostimulating effect on parasite tissues in both the parasympathetic and sympathetic regions. Moreover, it is presumed that this drug has an immunomodulatory effect on the host organism. Synonyms of this drug are decaris, solacil, ergamisol, tramisol, immunol, and others.

공급사50 곳

北京华美互利生物化工010-56205725 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
上海策嵘生物科技有限公司[email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]
추가 설명 · 1건

정의ChEBI: Levamisole is a 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine. It has a role as an antinematodal drug, an antirheumatic drug, an immunomodulator, an immunological adjuvant and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is an enantiomer of a dexamisole.

관련 반응

13건

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