기본 정보
- 표준 SMILES
c1ccc([C@H]2CN3CCSC3=N2)cc1- InChIKey
HLFSDGLLUJUHTE-SNVBAGLBSA-N- 분자식
- C11H12N2S
- 평균 분자량
- 204.29 g/mol
- 단동위원소 질량
- 204.07211956
이름 및 식별자
- 우선 이름
- Levamisole
- IUPAC
- (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
- 현지명
- 레바미졸
- 영어명
- Levamisole
- 분자식
- C11H12N2S
- 분자량
- 204.29
이름 및 동의어
이름 더 보기
데이터베이스 식별자
- CAS
14769-73-4- PubChem CID
- 26879
- DTXSID
DTXSID4023206- ChEMBL
CHEMBL1454- ChEBI
CHEBI:6432- UNII
- 2880D3468G
- EC Number
- 238-836-5
- Nikkaji
- J8.518I
물성
구조 계산 물성
- XLogP
- 1.8
- 극성 표면적
- 40.9 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 14
- 형식 전하
- 0
- 복잡도
- 246
물리화학적 성질
- 녹는점
- 60 · 60-61.5°
- 끓는 점
- 344.4 · 344.4±45.0 °C(Predicted)
- 밀도
- 1.32 · 1.32±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · Sealed in dry,2-8°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 10 · 10.00±0.40(Predicted)
- 색상
- 황백색에서 연한 노란색
- InChI
- InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
- InChIKey
- HLFSDGLLUJUHTE-SNVBAGLBSA-N
- SMILES
- S1CCN2C[C@H](C3=CC=CC=C3)N=C12
- EPA
- Levamisole (14769-73-4)
안전 및 규제
안전 데이터
- 기존화학 물질
- 97-3-152
화학 및 산업
응용 분야
용도Levamisole is used for initial and secondary immunodeficient conditions, autoimmune diseases, chronic and reoccurring infections, large intestine adenocarcinoma, helmintosis, and rheumatoid arthritis. Synonyms of this drug are decaris, tetramizole, and others.Levimasole is also a drug of choice for ascardiasis. Numerous investigations show that a single dose of levamisole heals from 90 to 100% of patients with ascardiasis, in particular those infected with A. duodenale. It is less effective against ancylostomiasis and strongyloidiasis. However, it is not effective against N. americanus. It seems likely that it has a gangliostimulating effect on parasite tissues in both the parasympathetic and sympathetic regions. Moreover, it is presumed that this drug has an immunomodulatory effect on the host organism. Synonyms of this drug are decaris, solacil, ergamisol, tramisol, immunol, and others.
상·하류 제품 정보
상류 원료
하류 제품
공급사50 곳
추가 설명
정의ChEBI: Levamisole is a 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine. It has a role as an antinematodal drug, an antirheumatic drug, an immunomodulator, an immunological adjuvant and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is an enantiomer of a dexamisole.
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