(-)-Epichlorohydrin (HCID 2734062)

이름 및 식별자

우선 이름: (-)-Epichlorohydrin
IUPAC: (2R)-2-(chloromethyl)oxirane
현지명: (R)-(？)-에피클로로히드린
영어명: (R)-(-)-Epichlorohydrin
분자식: C3H5ClO
분자량: 92.52

이름 및 동의어

(R)-(-)-Epichlorohydrin51594-55-9(-)-Epichlorohydrin(R)-(Chloromethyl)oxiraneEpichlorohydrin, (-)-VEC01H609IDTXSID501014417RefChem:590916DTXCID901437011424-280-2(R)-Epichlorohydrin(2R)-2-(chloromethyl)oxirane

이름 더 보기

(R)-(？)-에피클로로히드린R-1-클로로-2,3-에폭시프로판2-(Chloromethyl)oxiraneEPICHOLOROHYDRIN(R)-(-)-Epichlorohydorohydrin(R)-(−(R)-(-)-EpichLEPICHLOROHYDINEL-Epichlorohydrin

(R)-2-(Chloromethyl)OxiraneR-(-)-Epichlorohydrin(R)-3-chloro-1,2-epoxypropaneOxirane, (chloromethyl)-, (2R)-MFCD00077759(R)-1-Chloro-2,3-epoxypropaneOxirane, (chloromethyl)-, (R)-r-epichlorohydrin

데이터베이스 식별자

CAS: 51594-55-9
PubChem CID: 2734062
DTXSID: DTXSID501014417
ChEMBL: CHEMBL448626
ChEBI: CHEBI:18662
UNII: VEC01H609I
EC Number: 424-280-2、628-656-9
Nikkaji: J112.276B

물성

구조 계산 물성

XLogP: 0.5
극성 표면적: 12.5 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 1
회전 가능 결합 수: 1
무거운 원자 수: 5
형식 전하: 0
복잡도: 37

물리화학적 성질

녹는점: -48 °C · -48°C
끓는 점: 114 °C · 114 °C(lit.)
밀도: 1.18 g/mL · 1.180 g/mL at 20 °C(lit.)
증기 밀도: 3.29 · 3.29 (vs air)
증기압: 10 mm · 10 mm Hg ( 16.6 °C)
굴절률: 20 · n20/D 1.438(lit.)
인화점: 33 °C · 33 °C
저장 조건: 2 · 2-8°C
용해도: 클로로포름(소량으로 용해), 메탄올(약간 용해됨)
물리적 상태: 액체
색상: 투명한 무색~매우 연한 노란색
폭발한계: 21 % · 21%
수용성: 불용성
Merck: 14 · 14,3532
BRN: 1420785 · 1420785
InChI: 1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m0/s1
InChIKey: BRLQWZUYTZBJKN-VKHMYHEASA-N
SMILES: ClC[C@H]1CO1
NIST: Oxirane, (chloromethyl)-, (R)-(51594-55-9)

화학적 성질

Colorless to light yellow liqui

안전 및 규제

GHS 분류

GHS Classification · 6건

Danger

H226: Flammable liquid and vapor [Warning Flammable liquids]；H301: Toxic if swallowed [Danger Acute toxicity, oral]；H311: Toxic in contact with skin [Danger Acute toxicity, dermal]；H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H317: May cause an allergic skin reaction [Warning Sensitization, Skin]；H331: Toxic if inhaled [Danger Acute toxicity, inhalation]；H350: May cause cancer [Danger Carcinogenicity]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P270, P271, P272, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P318, P321, P330, P333+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Danger

유해성 정보

Regulatory Information · 2건

Hazard Traits - Carcinogenicity；Authoritative List - EC Annex VI CMRs - Cat. 1B；Report - if used as a fragrance or flavor ingredient

Status: Cease Manufacture Update: 20-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23063；Status: Active Update: 15-04-2011 https://echa.europa.eu/registration-dossier/-/registered-dossier/9019

Hazard Classes and Categories · 5건

Flam. Liq. 3 (100%)；Acute Tox. 3 (100%)；Acute Tox. 3 (100%)；Skin Corr. 1B (100%)；Skin Sens. 1 (100%)；Acute Tox. 3 (100%)；Carc. 1B (100%)；Repr. 2 (10.3%)

Flam. Liq. 3 (98.6%)；Acute Tox. 3 (98.6%)；Acute Tox. 3 (98.6%)；Skin Corr. 1B (98.6%)；Skin Sens. 1 (98.6%)；Acute Tox. 3 (97.2%)；Carc. 1B (98.6%)

Flammable liquid - category 3；Carcinogenicity - category 1B；Acute toxicity - category 3；Acute toxicity - category 3；Skin corrosion - category 1B；Skin sensitisation - category 1

Flammable liquids - Category 3；Acute toxicity (Oral) - Category 3；Acute toxicity (Dermal) - Category 3；Acute toxicity (Inhalation: Vapours) - Category 2；Skin corrosion/irritation - Category 1；Serious eye damage/eye irritation - Category 1；Respiratory sensitization - Category 1；Skin sensitization - Category 1；Germ cell mutagenicity - Category 2；Reproductive toxicity - Category 2；Specific target organ toxicity - Single exposure - Category 1 (kidney), Category 2 (liver, digestive system), Category 3 (respiratory tract irritation)；Specific target organ toxicity - Repeated exposure - Category 1 (digestive system, respiratory system, kidney, liver)

Flam. Liq. 3；Carc. 1B；Acute Tox. 3 *；Acute Tox. 3 *；Acute Tox. 3 *；Skin Corr. 1B；Skin Sens. 1

규제 정보

Regulatory Information · 2건

Hazard Traits - Carcinogenicity；Authoritative List - EC Annex VI CMRs - Cat. 1B；Report - if used as a fragrance or flavor ingredient

Status: Cease Manufacture Update: 20-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23063；Status: Active Update: 15-04-2011 https://echa.europa.eu/registration-dossier/-/registered-dossier/9019

안전 데이터

wgk: 3
tsca: Yes
rtecs: RR0427000
ridadr: UN 2023 6.1/PG 2
HS 번호: 29103000
risk_code: 45-10-23/24/25-34-43
hazard_code: T
safety_code: 53-45
포장분류: II
위험 등급: 6.1
기존화학 물질: KE-05-0591
자연 발화 온도: 772 °F
Hazard Classifications: Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralCarc. 1BEye Dam. 1Flam. Liq. 3Skin Corr. 1BSkin Sens. 1
스토리지 클래스: 3 - Flammable liquids
함량 및 규제정보: 물질구분: 유독물질; 혼합물(제품)함량정보: 에피클로로히드린 및 이를 0.1% 이상 함유한 혼합물
유해화학물질 필터링: 97-1-192
중점관리물질 필터링: 별표1-191

화학 및 산업

응용 분야 · 1건

용도((R)-Epichlorohydrin) R-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.