3-Fluoro-4-morpholinoaniline → (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol

HRID 18665

반응식

HRID 18665 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)[NH2:5].[CH2:15]1[O:17][C@H:16]1[CH2:18][Cl:19]>C(O)(C)C>[Cl:19][CH2:18][C@H:16]([OH:17])[CH2:15][NH:5][C:4]1[CH:6]=[CH:7][C:8]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[C:2]([F:1])[CH:3]=1

참가 물질

4

반응물 2

HCID 14853303-Fluoro-4-morpholinoanilineHCID 2734062(-)-Epichlorohydrin

생성물 1

HCID 16655948(2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol수율 99.3%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

3-Fluoro-4-morpholinyl aniline (39 g) is mixed with R-epichlorohydrin (18.5 g), isopropyl alcohol (200 ml) is added and heated for 16 hours at reflux temperature. The solvent is distilled to give 57 gm of N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline.

후처리

  1. additionis added
  2. temperatureheated for 16 hours
  3. temperatureat reflux temperature
  4. distillationThe solvent is distilled

출처 및 근거

ORD 기록
ord-be059e33dcdc4ec49c1e9eb1e2a24b02
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741480B2

연결된 노트

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