데이터를 보충하는 중입니다. 잠시 후 페이지를 새로 고치면 최신 내용을 볼 수 있습니다
기본 정보
- CAS
599150-20-6- 표준 SMILES
COCCOC(=O)C1=C(C)NC2=C(C(=O)CC(c3ccccc3OC)C2)C1c1cccc(O)c1- InChIKey
ZXSWZQSYZYMZKS-UHFFFAOYSA-N- 분자식
- C27H29NO6
- 평균 분자량
- 463.53 g/mol
- 단동위원소 질량
- 463.19948765
이름 및 식별자
- 우선 이름
- ST093553
- IUPAC
- 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
- 영어명
- 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
- 분자식
- C27H29NO6
- 분자량
- 463.52
이름 및 동의어
HPI 1GLI antagonist-1HPI 1, 10 mM in DMSOHedgehog Pathway Inhibitor 1Hh Signaling Antagonist XII, HPI-1HPI-1, hedgehog signaling inhibitorHh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroqui2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquino2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
데이터베이스 식별자
- CAS
599150-20-6- PubChem CID
- 2926768
- DTXSID
DTXSID90387857- ChEMBL
CHEMBL1243339- ChEBI
CHEBI:231759- EC Number
- 684-721-1
물성
물리화학적 성질
- 끓는 점
- 638.2 · 638.2±55.0 °C(Predicted)
- 밀도
- 1.28 · 1.28±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 용해도
- DMSO에 용해됨
- 산도 계수 (pKa)
- 9.67 · 9.67±0.10(Predicted)
- 물리적 상태
- 담황색 고체
- 색상
- Light yellow to yellow
- InChI
- 1S/C27H29NO6/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3
- InChIKey
- ZXSWZQSYZYMZKS-UHFFFAOYSA-N
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 2
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 22-50/53
- hazard_code
- Xn,N
- safety_code
- 60-61
- 위험 등급
- IRRITANT
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도HPI-1 is a Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor.
일반 설명A cell-permeable oxo-tetrahydroquinolinecarboxylate compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 1.5 & 3 μM, respectively) in a manner similar to two other Hh downstream blockers, HPI-3 (Cat. No. 373276) and GANT-61 (Cat. No. 373401). However, only HPI-1, but not HPI-3 or GANT-61 (no effect at 30 μM), remains effective against Sufu-/- fibroblasts overexpressing Gli1 or Gli2 (IC50 = 6 & 4 μM, respectively). HPI-1 is also shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing primary murine CGNPs (Cerebellar Granule Neuron Precursors) and NIH 3T3 (smoM2-LIGHT) cultures.
공급사19 곳
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
관련 반응
1건
화합물 노트
불러오는 중…