Fludarabine Phosphate

HCID 30751CAS 75607-67-9

기본 정보

표준 SMILES
Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]1O
InChIKey
GIUYCYHIANZCFB-FJFJXFQQSA-N
분자식
C10H13FN5O7P
평균 분자량
365.21 g/mol
단동위원소 질량
365.05366261

개요

Fludarabine phosphate is a purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. It has a role as an antiviral agent, an antimetabolite, an antineoplastic agent, an immunosuppressive agent, a prodrug and a DNA synthesis inhibitor. It is an organofluorine compound, a purine arabinonucleoside monophosphate and a nucleoside analogue. It is functionally related to a 2-fluoroadenine.

이름 및 식별자

우선 이름
Fludarabine Phosphate
IUPAC
[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

이름 및 동의어

fludarabine phosphate75607-67-9fludaraFludarabine 5'-monophosphateOfortaFludarabine monophosphate2-F-ara-AMPNSC-3128872-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine1X9VK9O1SCNSC 312887CHEBI:63599
이름 더 보기
2F-ara-AMPNSC-3280029-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)DTXSID20230609H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-F-ara-AMPFaraAMPfluoro-ara-AMP

데이터베이스 식별자

CAS
75607-67-9
PubChem CID
30751
DTXSID
DTXSID2023060
ChEMBL
CHEMBL1096882
ChEBI
CHEBI:63599
UNII
1X9VK9O1SC
EC Number
616-242-0
Nikkaji
J535.382C

물성

구조 계산 물성

XLogP
-3.1
극성 표면적
186 Ų
수소 결합 공여자 수
5
수소 결합 수용자 수
12
회전 가능 결합 수
4
무거운 원자 수
24

실험 및 물리화학적 성질

LogP-2.8
Solubility · 4건

2.97e+00 g/L

Water 9.2 (mg/mL)

pH 4 buffer 27.6 (mg/mL)

pH 9 buffer 57 (mg/mL)

Human Drugs · 2건

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Melting Point260 °C
Optical Rotation(c = 0.5, H2O) [a]21D = 12 ± 2°
Physical DescriptionSolid

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H341 (97.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 82 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesMuta. 2 (97.6%)

독성 정보

Exposure RoutesBioavailability is 55% following oral administration.
Toxicity Summary · 1건

Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Drug Induced Liver Injury · 6건

Drug Induced Liver Injury Rank (DILIrank 2.0)

Fludarabine phosphate

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

Toxicity DataMouse(iv): LD50: 1236 mg/kg

화학 및 산업

약리 정보

Metabolism/MetabolitesHalf Life: 20 hours
FDA Pharmacological Classification · 2건

FLUDARABINE PHOSPHATE

Nucleoside Metabolic Inhibitor [EPC]; Nucleic Acid Synthesis Inhibitors [MoA]

MeSH Pharmacological Classification · 2건

Antimetabolites that are useful in cancer chemotherapy.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Cellular LocationsCytoplasm

용도 및 제조

UsesFor the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen

관련 반응

4건

연결된 노트

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