Fludarabine Phosphate → Fludarabine phosphate magnesium salt

HRID 1003722

반응식

HRID 1003722 반응식
[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][O:16][P:17]([OH:20])([OH:19])=[O:18])[C@@H:12]([OH:21])[C@@H:11]2[OH:22])[C:8]2[C:3](=[C:4]([NH2:24])[N:5]=[C:6]([F:23])[N:7]=2)[N:2]=1.[O-2].[Mg+2:26]>O>[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:21])[C@@H:11]2[OH:22])[C:8]2[C:3](=[C:4]([NH2:24])[N:5]=[C:6]([F:23])[N:7]=2)[N:2]=1.[Mg+2:26].[P:17]([O-:20])([O-:19])([O-:18])=[O:16].[P:17]([O-:20])([O-:19])([O-:18])=[O:16].[Mg+2:26].[Mg+2:26]

참가 물질

4

반응물 2

HCID 30751Fludarabine PhosphateHCID 6850729Magnesium monoxide

생성물 1

HCID 86755286Fludarabine phosphate magnesium salt수율 95%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

10.0 g of fludarabine phosphate at a purity of 97.5% is suspended in 100 ml of water within about 5 minutes, and magnesium oxide is added to this solution. The mixture is stirred for one more hour at room temperature and then filtered. The clear solution is poured into 200 ml of acetone, stirred for 1 more hour, and the crystallizate is separated by filtration. 10.0 g (95% of theory) of the fludarabine-phosphate magnesium salt is obtained.

후처리

  1. filtrationfiltered
  2. additionThe clear solution is poured into 200 ml of acetone
  3. stirringstirred for 1 more hour
  4. customthe crystallizate is separated by filtration

출처 및 근거

ORD 기록
ord-51090bcb15194d508c3c7e0872bdadfc
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046322

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