N-(2-하이드록시프로필)메타크릴아미드

N-(2-하이드록시프로필)메타크릴아미드 · DK667 · DK668 · DKFELEX0166 · 2-Hydroxypropyl methacrylamide · N-(2-HYDROXYPROPYL)METHACRYLAMID · N-(2-Hydroxypropyl)methacrylamide · N-(2-Hydroxypropyl)methacrylamide,98%

https://huagongshe.com/ko/chemical/38622

식별자 및 물리적 특성

CAS No.	21442-01-3
분자식	C7H13NO2
평균 분자량	143.18 g/mol
단동위원소 질량	143.09462866 g/mol
SMILES	C=C(C)C(=O)NCC(C)O
InChIKey	OKPYIWASQZGASP-UHFFFAOYSA-N
PubChem CID	38622
EC No.	801-057-1
DTXSID	DTXSID30944024
현지명	N-(2-하이드록시프로필)메타크릴아미드

화학 및 물리적 성질

XLogP	0.3
극성 표면적	49.3
수소 결합 공여자 수	2
수소 결합 수용자 수	2
회전 가능 결합 수	3
무거운 원자 수	10
형식 전하	0
복잡도	143
녹는점	67.92°C
끓는 점	321.2±34.0 °C(Predicted)
밀도	1.002 g/mL ((predicted))
저장 조건	2-8°C
용해도	DMSO에 용해됨
pKa(산도 계수)	14.43±0.20(Predicted)
물리적 상태	가루
색상	White to off-white
InChI	1S/C7H13NO2/c1-5(2)7(10)8-4-6(3)9/h6,9H,1,4H2,2-3H3,(H,8,10)
InChIKey	OKPYIWASQZGASP-UHFFFAOYSA-N
SMILES	CC(O)CNC(=O)C(C)=C

안전 및 규제

GHS 분류	WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
수질 위해 등급(WGK)	3
관세 코드	2924297099
위험 문구(R)	36/37/38
안전 문구(S)	26-36/37/39
저장 분류	11 - Combustible Solids

용도

개요

N-(2-hydroxypropyl)methacrylamide (HPMA) is an important hydrophilic monomer. Due to the non-toxic, non-immunogenic properties and prolonged circulation time of both its homopolymers and copolymers, it is widely employed in the preparation of PHPMA copolymers (a polymer-drug conjugate) for use in the biopharmaceutical industry. For instance, poly(HPMA-co-MA-GFLG-doxorubicin) represents the first intravenous tumour-targeting polymeric prodrug to enter clinical trials. HPMA polymers and copolymers are also employed in the fabrication of biocompatible medical materials such as hydrogels[1].

용도

Monomers to synthesize biocompetible polymers and copolymers for drug carriers, protein conjugates and hydrogels in biomedical applications.