마니디핀
마니디핀 · Manidipine (Manyper) · Artedil · Iperten · Manidipine · Franidipine · Manidipine 6300 · Manidipine（base）
식별자 및 물리적 특성
| CAS No. | 89226-50-6 |
|---|---|
| 분자식 | C35H38N4O6 |
| 평균 분자량 | 610.7 g/mol |
| 단동위원소 질량 | 610.27913494 g/mol |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1 |
| InChIKey | ANEBWFXPVPTEET-UHFFFAOYSA-N |
| PubChem CID | 4008 |
| ChEMBL | CHEMBL1085699 |
| ChEBI | CHEBI:135849 |
| EC No. | 855-394-4 |
| DTXSID | DTXSID2043745 |
| 현지명 | 마니디핀 |
화학 및 물리적 성질
| XLogP | 5.6 |
|---|---|
| 극성 표면적 | 117 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 9 |
| 회전 가능 결합 수 | 11 |
| 무거운 원자 수 | 45 |
| 형식 전하 | 0 |
| 복잡도 | 1,090 |
| 용해도 | <1mg/mLSoluble in DMSO > 10 mM |
| 녹는점 | 125-128°C |
| 끓는 점 | 722.0±60.0 °C(Predicted) |
| 밀도 | 1.232±0.06 g/cm3(Predicted) |
| 저장 조건 | Sealed in dry,2-8°C |
| 물리적 상태 | 가루 |
| pKa(산도 계수) | 6.12±0.10(Predicted) |
| 색상 | Light yellow to yellow |
| LogP(분배 계수) | 4.135 |
화학적 성질
Light Yellow Crystalline Solid
안전 및 규제
| GHS 분류 | DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 3 reports by companies from 1 notifications to the ECHA C&L Inventory.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 규제 정보 | Status: Active Update: 11-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/33372 |
| Hazard Classes and Categories | Acute Tox. 3 (100%) |
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)ManidipineDILI PositiveDOI:10.1016/j.drudis.2019.09.022 |
| 신호 어 | Warning |
| 유해·위험 문구 | 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302 |
용도
개요
Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.
용도
Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It