아라키돈산

Arachidonic Acid

HCID 444899CAS 506-32-1

기본 정보

표준 SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O
InChIKey
YZXBAPSDXZZRGB-DOFZRALJSA-N
분자식
C20H32O2
평균 분자량
304.5 g/mol
단동위원소 질량
304.24023026

이름 및 식별자

우선 이름
Arachidonic Acid
IUPAC
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
현지명
아라키돈산
영어명
Arachidonic acid
분자식
C20H32O2
분자량
304.47

이름 및 동의어

arachidonic acid506-32-1(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid(all-Z)-5,8,11,14-Eicosatetraenoic acidcis-5,8,11,14-Eicosatetraenoic acid5Z,8Z,11Z,14Z-eicosatetraenoic acid5,8,11,14-Eicosatetraenoic acid, (all-Z)-all-cis-5,8,11,14-eicosatetraenoic acid27YG812J1I(5Z,8Z,11Z,14Z)-Icosatetraenoic acidC20:4DTXSID4040420
이름 더 보기
아라키돈산아라키도닉애씨드ARAArachidonateArachidonic5,8,11,14-EICOSATETRAENOIC ACIDicosa-5,8,11,14-tetraenoic acidArachidonic Acid (peroxide free)20:4n-6Single-Use Arachidonic Acid (peroxide free)
CHEBI:15843Arachidonate, SodiumRefChem:5560Fatty Acid 20:4 n-6DTXCID2020420All-cis-icosa-5,8,11,14-tetraenoic acid208-033-4Immunocytophyte

데이터베이스 식별자

CAS
506-32-1、93444-49-6
PubChem CID
444899
DTXSID
DTXSID4040420
ChEMBL
CHEMBL15594
ChEBI
CHEBI:15843
UNII
27YG812J1I
EC Number
208-033-4
Nikkaji
J12.228I

물성

구조 계산 물성

XLogP
6.3
극성 표면적
37.3 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
14
무거운 원자 수
22

실험 및 물리화학적 성질

LogP · 2건

6.98

6.98

Boiling Point170
Melting Point-49.5
Vapor Pressure0.00000015 [mmHg]
Physical Description · 2건

Liquid; [Merck Index]

Liquid

Kovats Retention Index2324.3

물리화학적 성질

녹는점
-49 °C · -49 °C (lit.)
끓는 점
169 · 169-171 °C/0.15 mmHg (lit.)
밀도
0.922 g/mL · 0.922 g/mL at 25 °C (lit.)
굴절률
20 · n20/D 1.4872(lit.)
인화점
230 °F · >230 °F
저장 조건
2 · 2-8°C
화학적 성질 · 1건

In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end. Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the term to all-cis-5,8,11,14- eicosatetraenoic acid.

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 10.3% (4 of 39) of reports.

Warning

H302 (84.6%): Harmful if swallowed [Warning Acute toxicity, oral];H312 (82.1%): Harmful in contact with skin [Warning Acute toxicity, dermal];H315 (89.7%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (89.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H332 (79.5%): Harmful if inhaled [Warning Acute toxicity, inhalation];H335 (84.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 4 of 39 reports by companies.;There are 5 notifications provided by 35 of 39 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 2건

Chemical: 5,8,11,14-Eicosatetraenoic acid, (all-Z)-

5,8,11,14-Eicosatetraenoic acid, (5Z,8Z,11Z,14Z)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards SummaryMay form explosive peroxides; May cause irritation; Targets the female reproductive system; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesAcute Tox. 4 (84.6%);Acute Tox. 4 (82.1%);Skin Irrit. 2 (89.7%);Eye Irrit. 2 (89.7%);Acute Tox. 4 (79.5%);STOT SE 3 (84.6%)

독성 정보

Toxicity Summary · 2건

The safety of this ingredient has not been documented and substantiated for cosmetic product use. The CIR Expert Panel cannot conclude whether Arachidonic Acid is safe for use in cosmetic products until such time that the appropriate safety data have been obtained and evaluated.

Ingredients for which the data are insufficient and their use in cosmetics is not supported

규제 정보

Regulatory Information · 2건

Chemical: 5,8,11,14-Eicosatetraenoic acid, (all-Z)-

5,8,11,14-Eicosatetraenoic acid, (5Z,8Z,11Z,14Z)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

안전 데이터

wgk
3
rtecs
CE6675000
ridadr
UN1170 - class 3 - PG 2 - Ethanol
독성
dns-mus:mmr 10 mg/L CRNGDP 5,1123,84
HS 번호
29161900
risk_code
19

화학 및 산업

약리 정보

Metabolism/MetabolitesArachidonic acid has known human metabolites that include 5,6-EET, 15-HETE, 8,9-EET, 14,15-EET, 11,12-EET, 13-HETE, 20-HETE, 11-HETE, 10-HETE, 18-HETE, 9-HETE, 8-HETE, 16-HETE, 19-HETE, 7-HETE, 12-HETE, 5-HETE, and 17-HETE.
Tissue LocationsAdipose Tissue;Epidermis;Fibroblasts;Intestine;Kidney;Liver;Lung;Neuron;Pancreas;Placenta;Platelet;Prostate;Skeletal Muscle;Spleen;Testis;Thyroid Gland
Cellular LocationsCytoplasm;Endoplasmic reticulum;Extracellular;Membrane
Metabolite Pathways · 1건

Acetaminophen Action Pathway;Acetylsalicylic Acid Action Pathway;alpha-Linolenic acid metabolism;Antipyrine Action Pathway;Antrafenine Action Pathway;Arachidonic Acid Metabolism;Bromfenac Action Pathway;Carprofen Action Pathway;Celecoxib Action Pathway;Diclofenac Action Pathway;Total 43 pathways, visit the HMDB page for details

용도 및 제조

Uses · 2건

CIR ingredient: Arachidonic Acid

Essential fatty acid for animals and humans; Used as a nutrient and for the treatment of eczema in dogs and swine; [Merck Index]

Use ClassificationCosmetics -> Emollient
응용 분야 · 3건

개요Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6). It is the counterpart to the saturated arachidic acid found in peanut oil, (L. arachis – peanut.).

용도Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.

일반 설명A Certified Spiking Solution suitable for use in mass spectrometry-based fatty acid testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of arachidonic acid in nutraceuticals and dietary supplements. Arachidonic acid (cis-5,8,11,14), sometimes referred to as AA or ARA, is a polyunsaturated omega-6 fatty acid. Studies suggests that ARA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders.

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
成都普瑞法科技开发有限公司+86-028-82633397 18982077548 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
爱斯特(成都)生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

추가 설명

정의ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.

관련 반응

42건

연결된 노트

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