기본 정보
- 표준 SMILES
Cn1cc(S(C)=O)c(=O)c2ccc(F)cc21- InChIKey
UYGONJYYUKVHDD-UHFFFAOYSA-N- 분자식
- C11H10FNO2S
- 평균 분자량
- 239.27 g/mol
- 단동위원소 질량
- 239.04162778
개요
Flosequinan is a member of quinolines.
이름 및 식별자
- 우선 이름
- Flosequinan
- IUPAC
- 7-fluoro-1-methyl-3-methylsulfinylquinolin-4-one
- 영어명
- Flosequinan
- 분자식
- C11H10FNO2S
- 분자량
- 239.27
이름 및 동의어
FLOSEQUINAN76568-02-0ManoplaxBTS-49465Flosequinanum4(1H)-Quinolinone, 7-fluoro-1-methyl-3-(methylsulfinyl)-DTXSID10488336NB119DLU7BTS-49-465DTXCID40287597-fluoro-3-methanesulfinyl-1-methyl-1,4-dihydroquinolin-4-one7-fluoro-1-methyl-3-methylsulfinyl-4-quinoline
이름 더 보기
FlosequinonFLOSEQUINAN USP/EP/BPFlosequinan, 10 mM in DMSO7-Huom-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone7-Fluoro-1-methyl-3-methylsulfinylquinolin-4(1H)-one7-Fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone
RefChem:599307C01DB017-Fluoro-1-methyl-3-(methylsulfinyl)quinolin-4(1H)-one7-fluoro-1-methyl-3-methylsulfinylquinolin-4-oneBTS 49 465NCGC00183849-017-fluoro-1-methyl-3-methylsulfinyl-4-quinoloneFlosequinanum [Latin]
데이터베이스 식별자
- CAS
76568-02-0- PubChem CID
- 4474062
- DTXSID
DTXSID1048833- ChEMBL
CHEMBL1908307- ChEBI
CHEBI:134972- UNII
- 6NB119DLU7
- Nikkaji
- J22.166J、J592.636J、J594.241A
물성
구조 계산 물성
- XLogP
- 1.1
- 극성 표면적
- 56.6 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 16
- 형식 전하
- 0
- 복잡도
- 369
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Cardiovascular system -> Cardiac therapy
물리화학적 성질
- 녹는점
- 226 · 226-228°
- 끓는 점
- 423.1 · 423.1±45.0 °C(Predicted)
- 밀도
- 1.44 · 1.44±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 산도 계수 (pKa)
- -0.51 · -0.51±0.70(Predicted)
화학 및 산업
약리 정보
ATC Code
C - Cardiovascular system
QC - Cardiovascular system
Metabolism/MetabolitesFlosequinan has known human metabolites that include flosequinan sulfone.
MeSH Pharmacological ClassificationDrugs used to cause dilation of the blood vessels.
응용 분야
개요Flosequinan is a new mixed arteriolar and venous vasodilator useful for the treatment of patients with congestive heart failure with or without ACE inhibitors, but especially in those patients who are intolerant to ACE inhibitors. It does not cause reflex stimulation of the renin-angiotensin or sympathetic nervous system. How flosequinan achieves its direct vasodilating effect is not clear, it is thought to interfere with protein kinase C and the production of inositol triphosphate. Flosequinan is well absorbed orally, and with the relatively long half-life of its sulfone metabolite it is suitable for once a day administration.
용도Antihypertensive (vasodilator).
상·하류 제품 정보
상류 원료
공급사12 곳
LGM Pharma1-(800)-881-8210 · [email protected]
United Life Science020-82099279 18988941402 · [email protected]
上海石洋化工有限公司021-56795766 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
赛诺威（厦门）科技有限公司请加微信(同手机号)或QQ询价 13876246362 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 +86-17392587031 · [email protected]
江苏艾康生物医药研发有限公司025-58851090 13913916777 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
南通韦恩迪医药科技有限公司18071612016 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
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