5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide → Flosequinan

HRID 1089771

반응식

HRID 1089771 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:17])[CH2:13][S:14]([CH3:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>[OH-].[Na+]>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:17])[C:13]([S:14]([CH3:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1

참가 물질

3

반응물 1

HCID 867447415'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide

생성물 1

HCID 4474062Flosequinan

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide (1.99 g), prepared in a similar manner to that described in Example 8, and aqueous sodium hydroxide solution (1M; 50 ml) was stirred for 2 hours at ambient temperature and then filtered. The solid was washed with water (2×10 ml) and then toluene (2×10 ml). The solid was dried at 50° in vacuo to give 7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone, m.p.228.5°-230° (1.55 g).

후처리

  1. customprepared in a similar manner to that
  2. filtrationfiltered
  3. washThe solid was washed with water (2×10 ml)
  4. customThe solid was dried at 50° in vacuo

출처 및 근거

ORD 기록
ord-753732c173054c95aa747eddf2a3d685
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05079264

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