기본 정보
- CAS
66794-74-9- 표준 SMILES
COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1.Cl- InChIKey
OJIIZIWOLTYOBS-UHFFFAOYSA-N- 분자식
- C22H29ClN2O2
- 평균 분자량
- 388.9 g/mol
- 단동위원소 질량
- 388.1917559
개요
Encainide hydrochloride is the hydrochloride salt of encainide. A class Ic antiarrhythmic, it was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. It has a role as an anti-arrhythmia drug. It contains an encainide.
이름 및 식별자
- 우선 이름
- Encainide Hydrochloride
- IUPAC
- 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide;hydrochloride
- 현지명
- 엔카이네이드염산염
- 영어명
- Encainide hydrochloride
- 분자식
- C22H28N2O2.ClH
- 분자량
- 388.936
이름 및 동의어
Encainide hydrochloride66794-74-9Encainide HClMJ 9067-1DTXSID2049004MJ-90674CH7J36N9S4-Methoxy-2'-(2-(1-methyl-2-piperidyl)ethyl)benzanilide hydrochlorideMJ-9067-1DTXCID7028930CHEBI:598802-(2-{2-[(4-methoxybenzoyl)amino]phenyl}ethyl)-1-methylpiperidinium chloride
이름 더 보기
엔카이네이드염산염(+)-IsomerEncainide, (+)-Isomer4-methoxy-n-(2-(2-(1-methylpiperidin-2-yl)ethyl)phenyl)benzamide hydrochlorideMJ-9067, (+/-)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide hydrochloride
2-(2-(2-((4-methoxybenzoyl)amino)phenyl)ethyl)-1-methylpiperidinium chlorideRefChem:920938Encainide Hydrochloride, (+-)-MJ9067Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)-, hydrochloride (1:1)636-281-7EnkaidEncainide (hydrochloride)
데이터베이스 식별자
- CAS
66794-74-9- PubChem CID
물성
구조 계산 물성
- 극성 표면적
- 41.6 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 27
- 형식 전하
- 0
- 복잡도
- 434
물리화학적 성질
- 녹는점
- 131.5 · 131.5-132.5 °C
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: >25mg/mL
- 물리적 상태
- 가루
- 색상
- White to off-white
- 수용성
- 2 O: · H2O: >25mg/mL
- InChI
- 1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H
- InChIKey
- OJIIZIWOLTYOBS-UHFFFAOYSA-N
- SMILES
- Cl.COc1ccc(cc1)C(=O)Nc2ccccc2CCC3CCCCN3C
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 3 (100%)
안전 데이터
- wgk
- 3
- rtecs
- CV5521500
- ridadr
- UN 2811 6.1/PG 3
- 독성
- LD50 in mice, dogs (mg/kg): 86, 43 orally; 16, 17 i.v. (Mitchell, Winkle)
- risk_code
- 25-36/37/38
- hazard_code
- T
- safety_code
- 26-45
- Hazard Classifications
- Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
응용 분야
개요Encainide is an oral and injectable antiarrhythmic structurally related to flecainide. It is reportedly useful in the treatment of symptomatic and life-threatening ventricular arrhythmias. While it appears to have higher efficacy than quinine, the morbidity and mortality rates are comparable.
용도Cardiac depressant (anti-arrhythmic.
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