기본 정보
- CAS
69049-74-7- 표준 SMILES
CCCc1c2oc(C(=O)[O-])cc(=O)c2cc2c(=O)cc(C(=O)[O-])n(CC)c12.[Na+].[Na+]- InChIKey
JQEKDNLKIVGXAU-UHFFFAOYSA-L- 분자식
- C19H15NNa2O7
- 평균 분자량
- 415.3 g/mol
- 단동위원소 질량
- 415.06439038
이름 및 식별자
- 우선 이름
- Nedocromil Sodium
- IUPAC
- disodium;9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylate
- 영어명
- NEDOCROMIL SODIUM
- 분자식
- C19H18NNaO7
- 분자량
- 395.34
이름 및 동의어
이름 더 보기
데이터베이스 식별자
- CAS
69049-74-7- PubChem CID
- 50295
- DTXSID
DTXSID00219115- ChEMBL
CHEMBL915- ChEBI
CHEBI:7493- UNII
- ET8IF4KS1T
- EC Number
- 620-501-3
- Nikkaji
- J357.902F
물성
구조 계산 물성
- 극성 표면적
- 127 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 742
물리화학적 성질
- 저장 조건
- 2 · Inert atmosphere,2-8°C
- 용해도
- 2 O: · H2O: 용해성20mg/mL, 투명
- 물리적 상태
- 가루
- 색상
- , 흰색에서 베이지색, 갈색
- 수용성
- 2 O: · H2O: 20mg/mL, clear
- InChI
- 1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2
- InChIKey
- JQEKDNLKIVGXAU-UHFFFAOYSA-L
- SMILES
- [Na+].[Na+].[n]1(c2c([c](cc1C(=O)[O-])=O)cc3c([o]c(c[c]3=O)C(=O)[O-])c2CCC)CC
안전 및 규제
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.
Warning
H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (83.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 1 of 6 reports by companies.;There are 2 notifications provided by 5 of 6 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
유해성 정보
Other Safety Information
IMAP assessments - 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt: Human health tier I assessment;IMAP assessments - 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt: Environment tier I assessment
안전 데이터
- wgk
- 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Substances that reduce or suppress INFLAMMATION.
Compounds that prevent the release of inflammatory mediators from MAST CELLS.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Drugs that are used to treat asthma.
응용 분야
개요Nedocromil sodium is an antiallergic agent with broader mast cell stabilizing properties than related cromolyn sodium. Administered as an aerosol, it is useful in the treatment of bronchial asthma and related diseases.
용도Nedocromil Sodium (Technical Grade) is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and other breathing problems caused by asthma.
일반 설명Nedocromil sodium, disodium9-ethyl-6, 9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3, 2-g]quinoline-2,8-dicarboxylate (Tilade), is structurally relatedto cromolyn and displays similar, but broader, pharmacologicalactions. It was available as an aerosol in ametered-dose inhaler for asthma treatment, and currently remainsavailable as ophthalmic solution for the treatmentof itching associated with allergic conjunctivitis. The inhalationformulation was marketed for maintenance therapyin the management of patients with mild-to-moderatebronchial asthma, but since has been withdrawn.
상·하류 제품 정보
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