Nedocromil Sodium

HCID 50295

기본 정보

CAS
69049-74-7
표준 SMILES
CCCc1c2oc(C(=O)[O-])cc(=O)c2cc2c(=O)cc(C(=O)[O-])n(CC)c12.[Na+].[Na+]
InChIKey
JQEKDNLKIVGXAU-UHFFFAOYSA-L
분자식
C19H15NNa2O7
평균 분자량
415.3 g/mol
단동위원소 질량
415.06439038

이름 및 식별자

우선 이름
Nedocromil Sodium
IUPAC
disodium;9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylate
영어명
NEDOCROMIL SODIUM
분자식
C19H18NNaO7
분자량
395.34

이름 및 동의어

NEDOCROMIL SODIUM69049-74-7TiladeAlocrilTayledFPL 59002KPRapitilTilarinNedocromil disodium saltFPL-59002KPET8IF4KS1TCHEBI:7493
이름 더 보기
NEDOCROMIL SODIUM###Nedocromil4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylicacid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, sodium salt
4H-Pyrano(3,2-g)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium saltDTXSID00219115RefChem:57534DTXCID20141606620-501-3Sodium 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylateNedocromil sodium [USAN]UNII-ET8IF4KS1T

데이터베이스 식별자

CAS
69049-74-7
PubChem CID
50295
DTXSID
DTXSID00219115
ChEMBL
CHEMBL915
ChEBI
CHEBI:7493
UNII
ET8IF4KS1T
EC Number
620-501-3
Nikkaji
J357.902F

물성

구조 계산 물성

극성 표면적
127 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
8
회전 가능 결합 수
3
무거운 원자 수
29

물리화학적 성질

저장 조건
2 · Inert atmosphere,2-8°C
용해도
2 O: · H2O: 용해성20mg/mL, 투명
물리적 상태
가루
색상
, 흰색에서 베이지색, 갈색
수용성
2 O: · H2O: 20mg/mL, clear
InChI
1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.

Warning

H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (83.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 1 of 6 reports by companies.;There are 2 notifications provided by 5 of 6 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Other Safety Information · 1건

IMAP assessments - 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt: Human health tier I assessment;IMAP assessments - 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt: Environment tier I assessment

Hazard Classes and CategoriesSkin Irrit. 2 (33.3%);Eye Irrit. 2 (83.3%);STOT SE 3 (33.3%)

안전 데이터

wgk
3
스토리지 클래스
11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 4건

Substances that reduce or suppress INFLAMMATION.

Compounds that prevent the release of inflammatory mediators from MAST CELLS.

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Drugs that are used to treat asthma.

응용 분야 · 3건

개요Nedocromil sodium is an antiallergic agent with broader mast cell stabilizing properties than related cromolyn sodium. Administered as an aerosol, it is useful in the treatment of bronchial asthma and related diseases.

용도Nedocromil Sodium (Technical Grade) is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and other breathing problems caused by asthma.

일반 설명Nedocromil sodium, disodium9-ethyl-6, 9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3, 2-g]quinoline-2,8-dicarboxylate (Tilade), is structurally relatedto cromolyn and displays similar, but broader, pharmacologicalactions. It was available as an aerosol in ametered-dose inhaler for asthma treatment, and currently remainsavailable as ophthalmic solution for the treatmentof itching associated with allergic conjunctivitis. The inhalationformulation was marketed for maintenance therapyin the management of patients with mild-to-moderatebronchial asthma, but since has been withdrawn.

공급사30 곳

陕西缔都新材料有限公司81124267 17392282731 · [email protected]
合肥曼奇诺生物医药技术有限公司19719236623 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

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