Calcium nitrate → Nedocromil Calcium

HRID 231806

반응식

HRID 231806 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]3[C:19](=[O:20])[CH:18]=[C:17]([C:21]([O-:23])=[O:22])[O:16][C:10]=3[C:11]=2[CH2:13][CH2:14][CH3:15])[C:6](=[O:24])[CH:5]=[C:4]1[C:25]([O-:27])=[O:26])[CH3:2].[Na+].[Na+].[N+]([O-])([O-])=O.[Ca+2:34].[N+]([O-])([O-])=O>O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]3[C:19](=[O:20])[CH:18]=[C:17]([C:21]([O-:23])=[O:22])[O:16][C:10]=3[C:11]=2[CH2:13][CH2:14][CH3:15])[C:6](=[O:24])[CH:5]=[C:4]1[C:25]([O-:27])=[O:26])[CH3:2].[Ca+2:34]

참가 물질

4

반응물 2

HCID 24963Calcium nitrateHCID 50295Nedocromil Sodium

생성물 1

HCID 68731Nedocromil Calcium수율 98.7%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A filtered solution of disodium 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano-[3,2-g]-quinoline-2,8-dicarboxylate (75 g) in water (500 ml) was treated with a filtered solution of calcium nitrate (77 g) in water (500 ml). The mixture was stirred (2 hours) and then filtered. The solid obtained was washed with water and acetone, slurried first with water and then reslurried with acetone (500 ml). The solid was filtered off and dried in vacuo at 65° C. to give the title compound (73 g, contains 19.3% w/w water).

후처리

  1. filtrationfiltered
  2. customThe solid obtained
  3. washwas washed with water and acetone
  4. filtrationThe solid was filtered off
  5. customdried in vacuo at 65° C.

출처 및 근거

ORD 기록
ord-57b3f8b9794a4e8fba9c5aa374d32808
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04849427

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