N-메틸피페라진

1-Methylpiperazine

HCID 53167CAS 109-01-3

기본 정보

표준 SMILES
CN1CCNCC1
InChIKey
PVOAHINGSUIXLS-UHFFFAOYSA-N
분자식
C5H12N2
평균 분자량
100.16 g/mol
단동위원소 질량
100.10004839

이름 및 식별자

우선 이름
1-Methylpiperazine
IUPAC
1-methylpiperazine
현지명
N-메틸피페라진
영어명
1-Methylpiperazine
분자식
C5H12N2
분자량
100.16

이름 및 동의어

1-MethylpiperazineN-Methylpiperazine109-01-3PIPERAZINE, 1-METHYL-1-methyl piperazineB92I95EL9QNSC-30195NSC-30675DTXSID4021898RefChem:434645DTXCID601898CHEBI:46920
이름 더 보기
1-메틸피페라진N-메틸피페라진NMPRZ1-MethyipiperazineN-MethylpiperazinPiperazine,1-methyl-CL046AKOS BBS-000036651-methyl-piperazin
203-639-54-Methylpiperazinen-methyl piperazine1-Methyl-piperazineMETHYLPIPERAZINEmethyl piperazineN-METHYL-PIPERAZINE1-methylpyperazine

데이터베이스 식별자

CAS
109-01-3
PubChem CID
53167
DTXSID
DTXSID4021898
ChEMBL
CHEMBL1011
ChEBI
CHEBI:166561
UNII
B92I95EL9Q
EC Number
203-639-5
Nikkaji
J1.011A

물성

구조 계산 물성

XLogP
-0.4
극성 표면적
15.3 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
0
무거운 원자 수
7

실험 및 물리화학적 성질

Vapor Pressure3.0 [mmHg]
Physical DescriptionClear light yellow hygroscopic liquid; [Sigma-Aldrich MSDS]
Kovats Retention Index · 2건

839;847;852;838.5

1266;1270;1274;1282;1282;1286;1262

물리화학적 성질

녹는점
-6 °C · -6 °C
끓는 점
138 °C · 138 °C(lit.)
밀도
0.903 g/mL · 0.903 g/mL at 25 °C(lit.)
증기 밀도
3.5 · 3.5 (vs air)
증기압
12 hPa · 12 hPa (20 °C)
굴절률
20 · n20/D 1.466(lit.)

화학적 성질

clear liquid

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 1.1% (4 of 377) of reports.

Danger

H226 (98.7%): Flammable liquid and vapor [Warning Flammable liquids];H312 (44.8%): Harmful in contact with skin [Warning Acute toxicity, dermal];H314 (98.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation];H317 (53.8%): May cause an allergic skin reaction [Warning Sensitization, Skin];H318 (51.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation];H330 (24.4%): Fatal if inhaled [Danger Acute toxicity, inhalation];H331 (12.5%): Toxic if inhaled [Danger Acute toxicity, inhalation];H332 (56.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P272, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P320, P321, P333+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 377 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 4 of 377 reports by companies.;There are 23 notifications provided by 373 of 377 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 4건

Chemical: Piperazine, 1-methyl-

Status: Active Update: 08-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13739;Status: Active Update: 20-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/18323

1-Methylpiperazine: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Hazards Summary · 1건

Causes skin corrosion in acute dermal studies of rabbits; Causes convulsions in acute inhalation studies of mice; Causes multiple liver effects, changes in renal tubules, changes in recording from peripheral motor nerve, and general anesthesia in acute oral studies of mice; [RTECS] Causes burns; May cause skin sensitization; Harmful by inhalation; [ECHA REACH Registrations] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by skin absorption; Toxic by inhalation; [Sigma-Aldrich MSDS] See Piperazine and salts.

Hazard Classes and Categories · 2건

Flam. Liq. 3 (98.7%);Acute Tox. 4 (44.8%);Skin Corr. 1B (98.9%);Skin Sens. 1B (53.8%);Eye Dam. 1 (51.7%);Acute Tox. 1 (24.4%);Acute Tox. 3 (12.5%);Acute Tox. 4 (56.8%)

Corrosives, Flammable agents - 2nd degree

독성 정보

Adverse Effects · 1건

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.;Dermatotoxin - Skin burns.;Skin Sensitizer - An agent that can induce an allergic reaction in the skin.;Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Toxicity DataLC50 (mouse) = 2,740 mg/m3/2hr

규제 정보

Regulatory Information · 4건

Chemical: Piperazine, 1-methyl-

Status: Active Update: 08-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13739;Status: Active Update: 20-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/18323

1-Methylpiperazine: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

안전 데이터

wgk
2
tsca
TSCA listed
rtecs
TM1225000
ridadr
UN 2734 8/PG 2
독성
LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg
HS 번호
29335995

화학 및 산업

용도 및 제조

UsesUsed to make large scale and fine chemicals; [ECHA REACH Registrations]
General Manufacturing InformationPiperazine, 1-methyl-: ACTIVE

응용 분야

용도N- 메틸 피페 라진 또는 N- 메틸 피페 라진은 리팜피신, 항 정신 이상제 트리 플루오로 페라 진, 오브 록 사신 등의 항균제 생산에 사용됩니다.그것은 주로 항 미세 요법 약물 인 2- (4- 메틸 -1- 피 페라 지닐 메틸) 아크릴 페논 (MPMAP)의 제조에 사용됩니다.

용도1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)

상·하류 제품 정보

하류 제품

AZIMILIDE3-(4-메틸피페라진-1-일)아닐린2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile1-아미노-4-미틸피페라진Zopiclone1-Methylpiperazine dihydrochloride2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine3-(4-메틸피페라진-1-일메틸)벤조산2-(4-메틸피페라진-1-일)피리미딘-5-카르복실산

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
爱斯特(成都)生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

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