Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
테마제팜
테마제팜 · 테마제팜(TEMAZEPAM) · er115 · k3917 · wy3917 · wy2917 · Planum · ER 115
식별자 및 물리적 특성
| CAS No. | 846-50-4 |
|---|---|
| 분자식 | C16H13ClN2O2 |
| 평균 분자량 | 300.74 g/mol |
| 단동위원소 질량 | 300.06655534 g/mol |
| SMILES | CN1C(=O)C(O)N=C(c2ccccc2)c2cc(Cl)ccc21 |
| InChIKey | SEQDDYPDSLOBDC-UHFFFAOYSA-N |
| PubChem CID | 5391 |
| ChEMBL | CHEMBL967 |
| ChEBI | CHEBI:9435 |
| EC No. | 212-688-1 |
| DTXSID | DTXSID8021309 |
| 현지명 | 테마제팜 |
화학 및 물리적 성질
| XLogP | 2.2 |
|---|---|
| 극성 표면적 | 52.9 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 21 |
| 형식 전하 | 0 |
| 복잡도 | 434 |
| 물질 분류 | Pharmaceutical |
| 의약품 | DEA NFLIS-Drug Category -> BenzodiazepinesDEA Schedule IV Controlled Substance -> DepressantsPharmaceuticalsPharmaceuticals -> HypnoticPharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds |
| LogP(분배 계수) | 3 |
| 용해도 | 5.34e-02 g/L물에는 거의 녹지 않으며, 염화메틸렌에는 잘 녹고, 에탄올에는 거의 녹지 않습니다(96%). |
| Human Drugs | Breast FeedingLactationMilk, HumanHypnotics and SedativesAnti-Anxiety AgentsBenzodiazepinesFDA approved drugs -> Active ingredientPharmaceuticals |
| 녹는점 | 119-121 °C119 - 121 °C119-121°C |
| Physical Description | Solid |
| Collision Cross Section | 166.1 Ų [M+H]+ [CCS Type: TWMethod: Major Mix IMS/Tof Calibration Kit (Waters)] |
| 끓는 점 | 211°C (rough estimate) |
| 밀도 | 1.2682 (rough estimate) |
| 굴절률 | 1.5200 (estimate) |
| 인화점 | 11 °C |
| 저장 조건 | 2-8°C |
| pKa(산도 계수) | pKa 1.6 (Uncertain) |
| BCS Class | 2 |
| EPA | Temazepam (846-50-4) |
화학적 성질
Crystalline Solid
안전 및 규제
| GHS 분류 | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 52 reports by companies from 7 notifications to the ECHA C&L Inventory. |
|---|---|
| 규제 정보 | Hazard Traits - Developmental ToxicityDEA schedule IV controlled substanceTemazepam: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-: Environment tier I assessment |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Treatment | If the patient is conscious, vomiting should be induced mechanically or with emetics. Gastric lavage should be employed utilizing concurrently a cuffed endotracheal tube if the patient is unconscious to prevent aspiration and pulmonary complications. Maintenance of adequate pulmonary ventilation is essential. The use of pressor agents intravenously may be necessary to combat hypotension. Fluids should be administered intravenously to encourage diuresis. (L1712) |
| 건강 영향 | They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. |
| Hepatotoxicity | Temazepam, like other benzodiazepines, is rarely associated with serum ALT elevations, and clinically apparent liver injury from temazepam is extremely rare, if it occurs at all. There have been no case reports of symptomatic, acute liver injury from temazepam. Isolated single cases of clinically apparent liver injury have been reported with other benzodiazepines including alprazolam, chlordiazepoxide, clonazepam, diazepam, flurazepam, lorazepam, and triazolam. The clinical pattern of acute liver injury from benzodiazepines is typically cholestatic and mild-to-moderate in severity with a latency of 1 to 6 months and rapid resolution with discontinuation. Fever and rash are uncommon as is autoantibody formation. |
| 유해 작용 | Adverse Drug Reactions |
| 노출 경로 | Oral, well absorbed, minimal first-pass metabolism. |
| 독성 요약 | Signs and Symptoms of Overdose |
용도
용도
Temazepam, is pharmacologically active metabolite of Diazepam (D416855). It is Sedative, and hypnotic. Controlled substance (depressant).
일반 설명
Temazepam, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl -2H-1,4-benzodiazepine-2-one(Restoril), also occurs as a minor metabolite of diazepam.It can be visualized as N-methyl oxazepam, and indeed, asmall amount of N-demethylation occurs slowly. However,metabolism proceeds mainly through glucuronidationof the 3-hydroxyl group, thus, it is intermediate acting andmarketed as a hypnotic said to have little or no residualeffect.