Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Arsenous acid
Arsenous acid (9CI) · Arsenous acid (as As) · GCPXMJHSNVMWNM-UHFFFAOYSA-N · Carbon Dioxide in Nitrogen (Nominal Amount-of-Substance Fraction 500 μmol/mol)
식별자 및 물리적 특성
| CAS No. | 13464-58-9 |
|---|---|
| 분자식 | AsH3O3 |
| 평균 분자량 | 125.944 g/mol |
| 단동위원소 질량 | 125.929814 g/mol |
| SMILES | O[As](O)O |
| InChIKey | GCPXMJHSNVMWNM-UHFFFAOYSA-N |
| PubChem CID | 545 |
| ChEMBL | CHEMBL1236189 |
| ChEBI | CHEBI:49900 |
| DTXSID | DTXSID7074828 |
화학 및 물리적 성질
| 극성 표면적 | 60.7 |
|---|---|
| 수소 결합 공여자 수 | 3 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 4 |
| 형식 전하 | 0 |
| 복잡도 | 8 |
| 물질 분류 | Metals -> Arsenic Compounds, Inorganic |
| 끓는 점 | 465 °C |
| Physical Description | SolidV (@25 °C) |
| 물리적 상태 | 용액에만 존재 |
| pKa(산도 계수) | 6.86±0.53(Predicted) |
| 색상 | exists only in solution |
| EPA | Arsenous acid (13464-58-9) |
화학적 성질
exists only in solution; is a weak acid, K=8×1016; structure: HO(OH)AsOH; preparation: 1 g As2O3, 5mL dilute HCl, dilute to 100mL with H2O; uses: for skin and blood disorders in animals [MER06] [KIR78]
안전 및 규제
| 유해성 요약 | See Arsenic and the linked occupational diseases. |
|---|---|
| 노출 관리 및 개인 보호 | Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/Lend of workweek |
| Minimum Risk Level | Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134) |
| Threshold Limit Values (TLV) | 0.01 [mg/m3], as As |
| Permissible Exposure Limit (PEL) | 0.01 [mg/m3], as As |
| Protective Action Criteria (PAC) | 0.050 [mg/m3]0.78 [mg/m3]4.7 [mg/m3] |
| Immediately Dangerous to Life or Health (IDLH) | 5.0 [mg/m3], as As |
| Treatment | Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20) |
| 건강 영향 | Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20) |
| 유해 작용 | Neurotoxin - Sensorimotor |
| 노출 경로 | Oral (L2)inhalation (L2)dermal (L2) |
| 독성 요약 | Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17) |
용도
용도
Pesticides.