포스미도마이신

Fosmidomycin

HCID 572CAS 66508-53-0

부분 구조 검색 유사 구조 찾기

기본 정보

표준 SMILES: O=CN(O)CCCP(=O)(O)O
InChIKey: GJXWDTUCERCKIX-UHFFFAOYSA-N
분자식: C4H10NO5P
평균 분자량: 183.1 g/mol
단동위원소 질량: 183.02965942

이름 및 식별자

우선 이름: Fosmidomycin
IUPAC: 3-[formyl(hydroxy)amino]propylphosphonic acid
현지명: 포스미도마이신
영어명: Fosmidomycin
분자식: C4H10NO5P
분자량: 183.1

이름 및 동의어

fosmidomycin66508-53-0FosmidomycinaFosmidomycineFosmidomycinum3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACIDFosmidomicina{3-[formyl(hydroxy)amino]propyl}phosphonic acid3-(N-hydroxyformamido)propylphosphonic acid5829E3D9I9CHEBI:443725DTXSID70216712

이름 더 보기

포스미도마이신Antibiotic FR-3170510 Mg, 50 Mg, 100 Mg, 1gFosmidomycin sodium hydrateFosmidomycin sodium salt hydrate3-Phosphono 1-(N-formylhydroxyamino)propane3-(Formylhydroxyamino)propylphosphonic acid(3-(N-hydroxyforMaMido)propyl)phosphonic acidPhosphonic acid, P-[3-(formylhydroxyamino)propyl]-(3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt

(3-(Formylhydroxyamino)propyl)phosphonic acid, monosodium salt3-(formyl-hydroxyamino)propylphosphonic acid3-(formyl(hydroxy)amino)propylphosphonic acid(3-(formyl(hydroxy)amino)propyl)phosphonic acidfosfidomycinRefChem:600353DTXCID001392033-(N-hydroxyfomamido)propylphosphonate

데이터베이스 식별자

CAS: 66508-53-0
PubChem CID: 572
DTXSID: DTXSID70216712
ChEMBL: CHEMBL203125
ChEBI: CHEBI:443725
UNII: 5829E3D9I9
Nikkaji: J431.386K

물성

구조 계산 물성

XLogP: -2.2
극성 표면적: 98.1 Å²
수소 결합 공여자 수: 3
수소 결합 수용자 수: 5
회전 가능 결합 수: 4
무거운 원자 수: 11
형식 전하: 0
복잡도: 166

물리화학적 성질

녹는점: 158 · 158-160° (dec); mp 160-166° (dec) (Hemmi)
저장 조건: -20 °C · -20°C
용해도: 2 O: · H2O: 용해성20mg/mL, 투명
물리적 상태: 가루
색상: 흰색에서 베이지색
수용성: 2 O: · H2O: 20mg/mL, clear
InChI: 1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10)
InChIKey: GJXWDTUCERCKIX-UHFFFAOYSA-N
SMILES: [P](=O)(O)(O)CCCN(O)C=O

안전 및 규제

안전 데이터

wgk: 3
독성: LD50 in mice and rats (mg/kg): >11000 orally; ~8000 s.c. (Wiesner, 2003)
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.

응용 분야

용도Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a study to determine monotropin carvacrol biosynthesis in Satureja khuzistanica plant.

공급사4 곳

广州爱纯医药科技有限公司020-39119399 18927568969 · [email protected]

BOC Sciences16314854226; +8616314854226 · [email protected]

苏州沃尔森生物科技有限公司18934576691 · [email protected]

TargetMol中国（陶术生物）15002134094 · [email protected]

추가 설명 · 1건

정의ChEBI: Propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme i the non-mevalonate pathway of isoprenoid biosynthesis.