Tetraethylammonium Chloride (HCID 5946)

개요

Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.

이름 및 식별자

우선 이름: Tetraethylammonium Chloride
IUPAC: tetraethylazanium chloride
현지명: 테트라에틸암모늄 염화물
영어명: Tetraethylammonium Chloride
분자식: C8H20ClN
분자량: 165.7

이름 및 동의어

TETRAETHYLAMMONIUM CHLORIDE56-34-8Etamon chlorideTea chlorideTEACN,N,N-Triethylethanaminium chlorideEthanaminium, N,N,N-triethyl-, chloridetetraethylazanium;chlorideDTXSID6041137CHEBI:781618B82Z83XNNDTXCID4021137

이름 더 보기

TetraethylammoniumtetraethylazaniuM chlorideSKL1479N2,2,2,2Clammonium chLEthamon chlorideTetraethylammonium choride

RefChem:188563Chloride, Tetraethylammonium200-267-5Tetraethyl ammonium chloridetetraethylammoniumchlorideEt4NClTetraethylammonium (chloride)EINECS 200-267-5

데이터베이스 식별자

CAS: 56-34-8
PubChem CID: 5946
DTXSID: DTXSID6041137
ChEMBL: CHEMBL434435
ChEBI: CHEBI:78161
UNII: 8B82Z83XNN
EC Number: 200-267-5

물성

구조 계산 물성

극성 표면적: 0 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 1
회전 가능 결합 수: 4
무거운 원자 수: 10
형식 전하: 0
복잡도: 47.5

실험 및 물리화학적 성질

Chemical ClassesNitrogen Compounds -> Quaternary Amines

Density1.08 @25 °C

Solubility20.3 [ug/mL] (The mean of the results at pH 7.4)

Vapor Pressure0.00000308 [mmHg]

Physical Description · 2건

Liquid

Deliquescent solid; [Merck Index] Colorless or light yellow hygroscopic crystals; [Sigma-Aldrich MSDS]

물리화학적 성질

녹는점: 39 °C · 39°C
끓는 점: 273.32 °C · 273.32°C (rough estimate)
밀도: 1.08 · 1.08
굴절률: 1.548 · 1.5480 (estimate)
저장 조건: Inert atmosphere,Room Temperature
용해도: 0.1 g/mL, · 메탄올: 0.1 g/mL, 투명, 무색
물리적 상태: 결정성 분말
색상: 흰색에서 밝은 노란색
수소이온지수(pH): 4 to · 4.0 to 7.0(50g/L, 25℃)
생물학적 소스: synthetic (organic)
수용성: 물, 에탄올, 클로로포름 또는 아세톤에 용해됨
Merck: 14 · 14,9200
BRN: 3563247 · 3563247
안정성: 안정적인. 강한 산화제와 호환되지 않습니다. 습기로부터 보호하십시오.
InChI: 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
InChIKey: YMBCJWGVCUEGHA-UHFFFAOYSA-M
SMILES: [Cl-].CC[N+](CC)(CC)CC
EPA: Tetraethylammonium chloride (56-34-8)

화학적 성질

Tetraethylammonium Chloride is a white crystalline powder. The solubility is 1000000 mg/L at 25 °C.

안전 및 규제

GHS 분류

GHS Classification · 6건

Warning

H302 (25.2%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 103 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

유해성 정보

Regulatory Information · 4건

Chemical: Ethanaminium, N,N,N-triethyl-, chloride (1:1)

Ethanaminium, N,N,N-triethyl-, chloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanaminium, N,N,N-triethyl-, chloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 06-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/20036

Ethanaminium, N,N,N-triethyl-, chloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Tetraethylammonium salts: Human health tier II assessment

Hazards Summary · 1건

Causes somnolence, tremor, and muscle weakness in oral, intraperitoneal, and intramuscular lethal-dose studies of mice and rats; Human intravenous injection of 5 mg/kg causes paresthesias, mydriasis, and ptosis; [RTECS] A skin and strong eye irritant; Targets the heart and CNS; [Sigma-Aldrich MSDS] See Tetraethylammonium bromide.

Hazard Classes and Categories · 2건

Acute Tox. 4 (25.2%)

Eye irritation - category 2B

안전 및 보호

Protective Action Criteria (PAC) · 3건

0.55 [mg/m3]

6.0 [mg/m3]

30 [mg/m3]

독성 정보

Adverse EffectsNeurotoxin - Other CNS neurotoxin

안전 데이터

wgk: 3
tsca: TSCA listed
rtecs: BS6125000
독성: LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)
HS 번호: 29239000
risk_code: 22-36/37/38
hazard_code: Xn,Xi
safety_code: 26-36-37/39
기존화학 물질: 2012-3-5572
F 고인화성물질: 3-10
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological ClassificationA class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.

용도 및 제조

UsesUsed as a catalyst (dehydrogenation and polymerization) and electrolyte (membrane transport studies); [Merck Index]

U.S. Production2023: 1,000,000 - <5,000,000 lb

Industry UsesIntermediate

General Manufacturing Information · 2건

All Other Basic Organic Chemical Manufacturing

Ethanaminium, N,N,N-triethyl-, chloride (1:1): ACTIVE

응용 분야 · 2건

용도Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.

일반 설명Visit our Sensor Applications portal to learn more.

상·하류 제품 정보

하류 제품

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

추가 설명 · 1건

정의ChEBI: Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.