Methanol → 4-Nitro-2-(trifluoromethyl)anisole

HRID 28249

반응식

HRID 28249 반응식
[OH-:1].[Na+].Cl[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:5]=1[C:13]([F:16])([F:15])[F:14].O.[CH3:18]O>[Cl-].C([N+](CC)(CC)CC)C>[CH3:18][O:1][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:5]=1[C:13]([F:16])([F:15])[F:14]

참가 물질

6

반응물 4

HCID 887MethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 612132-Chloro-5-nitrobenzotrifluoride

생성물 1

HCID 695624-Nitro-2-(trifluoromethyl)anisole수율 60.7%

시약·촉매·용매 1

HCID 5946Tetraethylammonium Chloride촉매

반응 조건

온도
30 °C

실험 절차

45 g of sodium hydroxide and 10 g of tetraethylammonium chloride in 200 g of methanol are initially introduced, 112.5 g of 2-chloro-5-nitro-benzotrifluoride are added dropwise at 25° to 30° C. and the mixture is then stirred at 30° C. for a further 5 hours. The mixture is then poured into 250 ml of water and extracted with methylene chloride. After evaporating off the solvent, the compound is recrystallised from isopropanol. 67 g of 2-methoxy-5-nitro-benzotrifluoride with a melting point of 70° to 74° C. are obtained.

후처리

  1. extractionextracted with methylene chloride
  2. customAfter evaporating off the solvent
  3. customthe compound is recrystallised from isopropanol

출처 및 근거

ORD 기록
ord-ce9d6417b525447fad8a7a50888eda11
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225731

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