Ethopabate
METHYL 4-ACETAMIDO-2-ETHOXYBENZOATE · Methyl 4-(acetylamino)-2-ethoxybenzoate · 4-Acetamido-2-ethoxybenzoic acid, methyl ester · Ethopatate · ETHOPABATE · Ethytpatate · Ethyl pabate · Isovaleraldehvde
식별자 및 물리적 특성
| CAS No. | 59-06-3 |
|---|---|
| 분자식 | C12H15NO4 |
| 평균 분자량 | 237.25 g/mol |
| 단동위원소 질량 | 237.10010796 g/mol |
| SMILES | CCOc1cc(NC(C)=O)ccc1C(=O)OC |
| InChIKey | GOVWOKSKFSBNGD-UHFFFAOYSA-N |
| PubChem CID | 6034 |
| ChEMBL | CHEMBL458769 |
| ChEBI | CHEBI:183844 |
| EC No. | 200-414-3 |
| DTXSID | DTXSID6046264 |
화학 및 물리적 성질
| XLogP | 1.2 |
|---|---|
| 극성 표면적 | 64.6 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 5 |
| 무거운 원자 수 | 17 |
| 형식 전하 | 0 |
| 복잡도 | 280 |
| Animal Drugs | Active Ingredients (Ethopabate) -> FDA GreenbookPharmaceuticals -> Animal Drugs -> Approved in Taiwan |
| 녹는점 | 148-151 °C |
| 끓는 점 | 426.1±35.0 °C(Predicted) |
| 밀도 | 1.180±0.06 g/cm3(Predicted) |
| 저장 조건 | Sealed in dry,Room Temperature |
| 용해도 | DMSO: 50 mg/mL (210.75 mM) |
| 물리적 상태 | 고체 |
| pKa(산도 계수) | 14.12±0.70(Predicted) |
| 색상 | White to off-white |
| Merck | 13,3781 |
| 주요 응용 | 법의학 및 독성학의약품(소분자) |
| InChI | InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14) |
| InChIKey | GOVWOKSKFSBNGD-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC |
| EPA | Ethopabate (59-06-3) |
화학적 성질
White to Off-White Solid
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 2.1% (1 of 48) of reports.WarningH302 (95.8%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 48 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Chemical: Benzoic acid, 4-(acetylamino)-2-ethoxy-, methyl ester |
| Hazard Classes and Categories | Acute Tox. 4 (95.8%) |
| 수질 위해 등급(WGK) | 3 |
| 관세 코드 | 2924296000 |
| 위험 문구(R) | 22 |
| 위험 표시 | Xn |
| 위험 등급 | Acute Tox. 4 OralEye Irrit. 2 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.
용도
A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.